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Chemotherapeutic Targets in Pneumocystis carinii

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Emerging Targets in Antibacterial and Antifungal Chemotherapy

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Abstract

P. carinii pneumonia, the most common life-threatening infection in patients with the acquired immunodeficiency syndrome (AIDS) as well as the most common index diagnosis in AIDS, is caused by an enigmatic pathogen whose metabolism and basic biology are poorly understood (11,12,16). Prior to AIDS, P. carinii pneumonia was largely a rare disease of immunosuppressed children, with a yearly incidence of fewer than 100 cases in the early 1970s (96). The AIDS epidemic has made P. carinii pneumonia an enormously important public health problem; it has become among the most frequent causes of pneumonia requiring hospitalization and is probably the most common cause of death in AIDS. A recent estimate predicts 150,000 cases of P. carinii pneumonia in the next 3–4 years (35). Approximately 80% of patients with AIDS will have at least one episode of P. carinii pneumonia (67). The incidence of P. carinii pneumonia in patients with cancer may also be rising (32), further highlighting the need for improved diagnosis, therapy, and prophylaxis of this once-obscure illness.

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Authors
  1. Gregg Y. Lipschik
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  2. Joseph A. Kovacs
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Editors and Affiliations

  1. Department of Chemotherapy (58/2), Roche Research Center, Nutley, NJ, 07110-1199, USA

    Nafsika H. Georgopapadakou

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© 1992 Springer Science+Business Media Dordrecht

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Lipschik, G.Y., Kovacs, J.A. (1992). Chemotherapeutic Targets in Pneumocystis carinii . In: Sutcliffe, J.A., Georgopapadakou, N.H. (eds) Emerging Targets in Antibacterial and Antifungal Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3274-3_22

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  • DOI: https://doi.org/10.1007/978-1-4615-3274-3_22

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