Abstract
Several studies have shown that during the development of respiratory failure in the adult respiratory distress syndrome (ARDS), the pulmonary surfactant system is disturbed1–5. One of the current promising therapeutic approaches in ARDS is, therefore, re-establishment of the functional integrity of the damaged surfactant system by intratracheal instillation of surfactant. The first clinical trials6,7 and results from experimental studies on ARDS have shown that exogenous surfactant application can restore lung function in ARDS (for review see references 8 and 9). Due to the great variance in etiology of ARDS it is, however, a necessity to investigate surfactant replacement therapy in different models of respiratory failure. Therefore, we studied the effect of surfactant substitution in two animal models of severe respiratory failure due to viral pneumonia.
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van’t Veen, A., So, K.L., Lachmann, B. (1994). Surfactant Replacement Therapy in Animal Models of Respiratory Failure Due to Viral Infection. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_11
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_11
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