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Lactic Acid Bacteria as Mucosal Delivery Vehicles

  • Chapter
Genetics of Lactic Acid Bacteria

Part of the book series: The Lactic Acid Bacteria ((LAAB,volume 3))

Abstract

The development of effective strategies for the delivery of vaccine antigens to the mucosal tissues has received considerable attention over the past decade (reviewed in Michalek et al., 1994; O’Hagan, 1994; Wells and Pozzi, 1997). The main advantage of this route of administration is that it has the potential to elicit local immune responses leading to the production of antigen-specific secretory immunoglobulin A (sIgA) as well as systemic immune responses. Other advantages include low cost, ease of administration and minimization of adverse effects.

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  1. Annick Mercenier (Head of Department)

    Present address: Nestlé Research Centre, CH-1000, Lausanne 26, Switzerland

Authors and Affiliations

  1. Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, UK

    Jerry M. Wells (Head of Bacterial Infection and Immunology)

  2. Microbiology of Ecosystems, Institut Pasteur de Lille, 1, rue du Prof Calmette, BP245, 59019, Lille Cedex, France

    Annick Mercenier (Head of Department)

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  1. Jerry M. Wells
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  1. Strathclyde University, Glasgow, Scotland

    Brian J. B. Wood

  2. Cranfield University at Silsoe, Bedfordshire, UK

    Philip J. Warner

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Wells, J.M., Mercenier, A. (2003). Lactic Acid Bacteria as Mucosal Delivery Vehicles. In: Wood, B.J.B., Warner, P.J. (eds) Genetics of Lactic Acid Bacteria. The Lactic Acid Bacteria, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0191-6_9

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