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Porous Systems

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Fundamentals and Applications of Controlled Release Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Porous systems play a significant role in controlled release. Porous membranes and matrices can be used to store drug prior to release, and pore structure plays a significant role in determining release kinetic profiles. In this chapter we review methods used to measure pore structure and mathematical models used to relate pore structure to drug transport properties. Steric and hydrodynamic interactions between drug and pore walls, pore tortuosity, and variation in pore width are identified as factors affecting transport. Percolation theory, which addresses connectedness of random pore networks and its effect on overall releasability of drug and release rate, is discussed. Concepts developed for porous systems can be applied, with some modifications, to transport in other heterogeneous systems, such as tissue interstitium and hydrogels.

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Author information

Authors and Affiliations

  1. Departments of Pharmaceutics and Biomedical Engineering, University of Minnesota, Minneapolis, MN, 55419, USA

    Ronald A. Siegel

  2. Department of Pharmaceutics WDH 9-177, University of Minnesota, 308 Harvard St. S.E., Minneapolis, MN, 55455, USA

    Ronald A. Siegel

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  1. Ronald A. Siegel
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Correspondence to Ronald A. Siegel .

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Editors and Affiliations

  1. Rue Maurice Schumann 3, Phalempin, 59133, France

    Juergen Siepmann

  2. , Department of Pharmaceutics, University of Minnesota, Harvard Street SE 308, Minneapolis, 55455, Minnesota, USA

    Ronald A. Siegel

  3. , School of Pharmacy, Griffith University, Parklands Drive 1, Southport, 4215, Queensland, Australia

    Michael J. Rathbone

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Siegel, R.A. (2012). Porous Systems. In: Siepmann, J., Siegel, R., Rathbone, M. (eds) Fundamentals and Applications of Controlled Release Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0881-9_9

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