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Biological Rhythms, Drug Delivery, and Chronotherapeutics

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Fundamentals and Applications of Controlled Release Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Biological processes are highly structured in time as endogenously derived rhythms of short, intermediate, and long periods, with the circadian (24h) time structure most studied. Staging of key physiological and biochemical circadian rhythms gives rise to 24-h patterns in the exacerbation of chronic medical conditions, including arthritis, asthma, ulcer, and hypertension, plus manifestation of acute severe morbid and mortal events, such as myocardial infarction, stroke, and sudden cardiac death. Body rhythms may also significantly affect patient response to diagnostic tests and pharmacokinetics, pharmacodynamics, and toxicities of diverse classes of medications. This chapter reviews circadian and other period biological rhythm dependencies of the pathophysiology of disease and pharmacology of medications as the basis for chronotherapeutics and development of time-modulated drug-delivery systems.

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Authors and Affiliations

  1. Department Biomedical Engineering, The University of Texas at Austin, 1 University Station, CO800, Austin, TX, 78712-0238, USA

    Michael H. Smolensky

  2. Departments of Pharmaceutics and Biomedical Engineering, University of Minnesota, Minneapolis, MN, 55419, USA

    Ronald A. Siegel

  3. Department of Pharmaceutics WDH 9-177, University of Minnesota, 308 Harvard St. S.E., Minneapolis, MN, 55455, USA

    Ronald A. Siegel

  4. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA

    Erhard Haus

  5. HealthPartners Medical Group, Regions Hospital, St. Paul, MN, USA

    Erhard Haus

  6. Bioengineering & Chronobiology Laboratories, University of Vigo, Campus Universitario, Vigo, Spain

    Ramon Hermida

  7. Department of Clinical and Experimental Medicine, Hypertension Center, University Hospital S. Anna, University of Ferrara, Ferrara, Italy

    Francesco Portaluppi

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  1. Michael H. Smolensky
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  2. Ronald A. Siegel
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  3. Erhard Haus
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  4. Ramon Hermida
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  5. Francesco Portaluppi
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Correspondence to Michael H. Smolensky .

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  1. Rue Maurice Schumann 3, Phalempin, 59133, France

    Juergen Siepmann

  2. , Department of Pharmaceutics, University of Minnesota, Harvard Street SE 308, Minneapolis, 55455, Minnesota, USA

    Ronald A. Siegel

  3. , School of Pharmacy, Griffith University, Parklands Drive 1, Southport, 4215, Queensland, Australia

    Michael J. Rathbone

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Smolensky, M.H., Siegel, R.A., Haus, E., Hermida, R., Portaluppi, F. (2012). Biological Rhythms, Drug Delivery, and Chronotherapeutics. In: Siepmann, J., Siegel, R., Rathbone, M. (eds) Fundamentals and Applications of Controlled Release Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0881-9_13

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