Abstract
One mechanism that cells and organisms can employ to increase the level of gene expression is that of specific gene amplification. This process has been most intensively studied in tumor cells exhibiting amplification of cellular oncogenes and cultured mammalian cells selected for resistance to drugs (1,2), though it also occurs in a developmentally-regulated manner in Xenopus (3) and Drosophila (4). In the laboratory gene amplification has been shown to occur in human parasites, including drug-resistant lines of three species of Leishmania (5–3) and in Plasmodium falciparum (9).
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Beverley, S.M., Ellenberger, T.E., Petrillo-Peixoto, M. (1989). Unstable and Stable Gene Amplification in Methotrexate-Resistant Leishmania Major and Natural Isolates of Leishmania Tarentolae. In: Hart, D.T. (eds) Leishmaniasis. NATO ASI Series, vol 171. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1575-9_109
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DOI: https://doi.org/10.1007/978-1-4613-1575-9_109
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