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Calcium and Vitamin D

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Comprehensive Management of Menopause

Part of the book series: Clinical Perspectives in Obstetrics and Gynecology ((CPOG))

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Abstract

Osteoporosis is a major health issue in all Western countries, affecting approximately 25% to 30% of all postmenopausal women. It is not a disease with a single cause but rather a heterogeneous disease process involving a number of contributing etiologic factors.1 It is well established that skeletal mass diminishes with aging but the relative contributions of genetic and environmental factors are still unknown.2

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References

  1. Riggs BL. Pathogenesis of osteoporosis. Am J Obstet Gyncol. 1987;156:1342–1346.

    CAS  Google Scholar 

  2. Heaney RP, Gallagher JC, Johnston CC, et al. Calcium nutrition and bone health in elderly. Am J Clin Nutr. 1982;36:986–1013.

    PubMed  CAS  Google Scholar 

  3. Raisz LG. Osteoporosis. J Am Geriatr Soc 1982;30:127–138.

    CAS  Google Scholar 

  4. Dawson-Hughes B. Osteoporosis and aging: gastrointestinal aspects. J Am Coll Nutr. 1986; 5:393–398.

    PubMed  CAS  Google Scholar 

  5. Heaney RP, Recker RR. Effects of nitrogen, phosphorus, and caffeine on calcium balance in women. J Lab Clin Med. 1982;99:46–55.

    PubMed  CAS  Google Scholar 

  6. Heaney RP, Recker RR, Stegman MR, Moy AJ. Calcium absorption in women: relationships to calcium intake, estrogen status and age. J Bone Min Res. 1989;4:469–475.

    Article  CAS  Google Scholar 

  7. Nordin BEC, ed. Calcium, Phosphate and Magnesium Metabolism. New York, NY: Churchill Livingstone; 1976.

    Google Scholar 

  8. Matkovic V, Kostial K, Simonivoc I, et al. Bone status and fracture rates in two regions in Yugoslavia. Am J Clin Nutr. 1979;32:540–549.

    PubMed  CAS  Google Scholar 

  9. Garn SM. The earlier gain and the later loss of cortical bone in nutritional perspective. Springfield, IL: Charles C Thomas; 1970.

    Google Scholar 

  10. Smith RW, Frame B. Concurrent axial and appendicular osteoporosis: its relation to calcium consumption. N Engl J Med. 1986;273: 72–78.

    Google Scholar 

  11. Caroll MD, Abrahams S, Dresser CM. Dietary intake source data, United States, 1976–80 (PHS 83–1681). National Center for Health Statistics. Washington, DC: Government Printing Office; March 1983.

    Google Scholar 

  12. Scythes CA, Gibson RS, Draper HH. Dietary calcium and phosphorus intakes of a sample of Canadian premenopausal women consuming self-selected diets. Nutr Res. 1982;2:385–396.

    Article  Google Scholar 

  13. Delvin EE, Imbach A, Copti M. Vitamin D nutritional status and related biochemical indices in an autonomous elderly population. Am J Clin Nutr. 1988;48:373–378.

    PubMed  CAS  Google Scholar 

  14. Morgan DB. Osteomalacia, renal osteodystrophy and osteoporosis. Springfield, IL: CC Thomas; 1973.

    Google Scholar 

  15. Cummings JH, Hill MJ, Jivraj T, Houston H, Branch WJ, Jenkins DJA. The effect of meat protein and dietary fiber on colonic function and metabolism, I. Changes bowel habit, bile acid excretion and calcium absorption. Am J Clin Nutr. 1979;32:2086–2093.

    PubMed  CAS  Google Scholar 

  16. Kelsay J., Behall KM, Prather ES. Effect of fiber from fruits and vegetables on metabolic responses of human subjects. II. Calcium, magnesium, iron and silicon balances. Am J Clin Nutri. 1979;32:1876–1880.

    CAS  Google Scholar 

  17. Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, De Luca HF. Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium.J Clin Invest. 1979;64:729–736.

    Article  PubMed  CAS  Google Scholar 

  18. Newcomer AD, Hodgson SF, McGill DB, Thomas PJ. Lactase deficiency: prevalance in osteoporosis. Ann Intern Med. 1978;89:218–220

    PubMed  CAS  Google Scholar 

  19. Donath A, Nordio S, Macagno F, Gatti R. The effect of hydrochlorothiazide on calcium and strontium transport in intestine and kidney. Heiv Paediat Acta. 1971;25:293–300.

    Google Scholar 

  20. Gursel E. Effects of diuretics on renal and intestinal handling of calcium. N.Y. State J Med. 1970;70:399–405.

    PubMed  CAS  Google Scholar 

  21. Harrison AR, Ross GA. The effect of bendrofluozide on urinary and faecal calcium and phosphorus. Clin Sci. 1986;34:343–350.

    Google Scholar 

  22. LaCroix AZ, Wienpahl J, White LR, et al. Thiazide diuretics and the incidence of hip fractures. N Engl J Med. 1990;322:286–290.

    Article  PubMed  CAS  Google Scholar 

  23. Dent CE, Richens A, Rowe DKF, Stamp TCB. Osteomalacia with long-term anticonvulsant therapy in epilepsy. Brit Med J. 1970;4:69–72.

    Article  PubMed  CAS  Google Scholar 

  24. Saville D. Changes in bone mass with age and alcoholism. J Bone Joint Surg. 1965;47A:492–499.

    Google Scholar 

  25. Nilsson BE, Bestlin NE. Changes in bone mass in alcoholics. Clin Orthop. 1973;90:229–232.

    PubMed  Google Scholar 

  26. Spencer H, Lender M. Adverse effects of aluminum-containing antacid or mineral metabolism. Gastroenterology. 1979;76:603–606.

    PubMed  CAS  Google Scholar 

  27. Spencer H, Kramer L, Osis D, Norris C. Effect of phosphorus on the absorption of calcium and on the calcium balance in man. J Nutr. 1978;108:7–57.

    Google Scholar 

  28. McParland BE, Goulding A, Campbell AJ. Dietary salt affects biochemical markers of resorption and formation of bone in elderly women. Brit Med J. 1989;299:834–835.

    Article  PubMed  CAS  Google Scholar 

  29. Need AG, Morris HA, Cleghorn DB, DeNichilo D, Horowitz M, Nordin BEC. Effect of salt in postmenopausal women. Arch Int Med. 1991;151:757–764.

    Article  CAS  Google Scholar 

  30. Johnson NE, Alcantara EN, Linkswiler HM. Effect of protein intake on urinary and fecal calcium and calcium retention of young adult males. J Nutr. 1970;100:1425–1428.

    PubMed  CAS  Google Scholar 

  31. Nordin BEC. The pathogenesis of osteoporo sis. Lancet. 1961;1:1011–1014.

    Article  PubMed  CAS  Google Scholar 

  32. Stepan JJ, Pospichal J, Presl J, Packovsky V. Bone loss and biochemical indices of bone remodelling in surgically induced postmeno pausal women. Bone. 1987;8:279–284.

    Article  PubMed  CAS  Google Scholar 

  33. Heaney RP, Recker RR, Saville PD. Menopausal changes in bone remodeling. J Lab Clin Med. 1978;92:964–970.

    PubMed  CAS  Google Scholar 

  34. Gallagher JC, Goldgar D, Moy A. Total bone calcium in normal women: effect of age and menopause status. J Bone Min Res. 1987;2: 491–496.

    Article  CAS  Google Scholar 

  35. Gennari C, Agnusdei D, Nardi P, Civitelli R. Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women. J Clin Endocrinol Metab. 1990;71:1288–1293.

    Article  PubMed  CAS  Google Scholar 

  36. Heaney RP, Recker RR, Saville PD. Meno pausal changes in calcium balance perfor mance. J Lab Clin Med. 1978;92:953–963.

    PubMed  CAS  Google Scholar 

  37. Riffs B, Thomsen K, Christiansen C. Does calcium supplementation prevent postmenopausal bone loss? N Engl J Med. 1987;316:173–177

    Article  Google Scholar 

  38. National Institutes of Health Osteoporosis Consensus Development Conference Statement. JAMA. 1984;252:799–802.

    Article  Google Scholar 

  39. Bullamore JR, Wilkinson R, Gallagher JC, Nordin BEC, Marshall DH. Effect of age on calcium absorption. Lancet. 1970;2:535–537.

    Article  PubMed  CAS  Google Scholar 

  40. Ireland P, Fordtran JS. Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J Clin Invest. 1973;52:2672–2681.

    Article  PubMed  CAS  Google Scholar 

  41. Ackerman PG, Toro G. Calcium balance in elderly women. J Gerontol. 1954;9:446–449.

    Google Scholar 

  42. Sutnick MR. Nutrition: calcium, cholesterol and calories. Med Clin North Am. 1987;71:123–134.

    PubMed  CAS  Google Scholar 

  43. Fisher CJ. Nutrition’s role in determining the quality of life. Geriatric Medicine. 1986;2:183–186.

    Google Scholar 

  44. Allen LH. Calcium bioavailability and absorption: a review. Am J Clin Nutr. 1982;35:783–808.

    PubMed  CAS  Google Scholar 

  45. Kaye M. Dietary calcium and calcium supplerestriction on urine hydroxyproline excretion mentation. Mod Med Canada. 1986;41:3–12.

    Google Scholar 

  46. Gorecki D, Richardson J, et al. Dissolution rates in calcium carbonate tablets, a consid eration in product selection. Can Pharm J. 1989;144:485–508.

    Google Scholar 

  47. Recker RR. Calcium absorption and achlorhydria. N Eng J Med. 1985;313:70–73.

    Article  CAS  Google Scholar 

  48. Carr CJ, Shangraw RF. Nutritional and pharmaceutical aspects of calcium supplementation. Am Pharm. 1987;27:49.

    Google Scholar 

  49. Pak CV, Khashayar S, et al. Nephrolithiasis from calcium supplementation. J Urol. 1987; 137:1212–1213.

    PubMed  CAS  Google Scholar 

  50. Keyler D, Peterson CD. Oral calcium supplements: how much of what, for whom, and why? Postgrad Med. 1985;78:123–125.

    PubMed  CAS  Google Scholar 

  51. Khashayar S, Nicar MJ, Glass K, Zerwekn JE, Pak CYC. Reduction in intestinal calcium absorption by hydrochlorthiazide in postmeno pausal osteoporosis. J Clin Endocrinol Metab. 1984;59:1037–1043.

    Article  Google Scholar 

  52. Calcium supplements (Systemic). In: United States Pharmacopeial Convention USP DI, VOl1A, Drug Information for the Health Care Professional. Rockville: United States Pharmacopeial Convention; 1991:766–775.

    Google Scholar 

  53. Storm T, Thamsborg G, et al. Effect of inter mittent cyclical etidronate therapy on bone mass and fracture rate in women with post menopausal osteoporosis. N Eng J Med. 1990; 332;1265–1271.

    Article  Google Scholar 

  54. Arnold R, Wermeille M, et al. Influence of food and antiacid administration of fluoride bioavailability from enteric-coated sodium fluoride tablets. Bone. 1989;10:401–407.

    Article  PubMed  CAS  Google Scholar 

  55. Drug interactions facts. ed. D.S. Tatro. St. Louis: J.B. Lippincott Company; 1993:43.

    Google Scholar 

  56. Calcium salts. In: Physician’s 1989 Drug Handbook. Pennsylvania: Springhouse; 1989: 155–157.

    Google Scholar 

  57. Reid IR., Schooler BA, Hannan SF, Ibbertson HK. The acute biochemical effects of four proprietary calcium preparations. Aust N Z J Med. 1986;16:193–197.

    Article  PubMed  CAS  Google Scholar 

  58. Food and Drug Administration. Advice on limiting intake of bone meal. FDA Drug Bull. 1982;12:5–6.

    Google Scholar 

  59. Stamp TCB, Haddad JG, Twigg CA. Comparison of oral 25-hydroxycholecalciferol, vitamin D, and ultraviolet light as determinants of circulating 25-hydroxyvitamin D. Lancet. 1977;1:1341–1343.

    Article  PubMed  CAS  Google Scholar 

  60. Stamp TCB, Round JM. Seasonal changes in human plasma levels of 25-hydroxyvitamin D. Nature. 1974;247:563–565.

    Article  PubMed  CAS  Google Scholar 

  61. Roginsky MS, Moo HF, Abesamis C. Season variations in serum 25-hydroxycholecalciferol. Lancet. 1974;1:1235–1236.

    Article  PubMed  CAS  Google Scholar 

  62. Bouillon RA, Auwerx JH, Lissens WD, Pelemans WK. Vitamin D status in the elderly: season substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency. Am J Clin Nutr. 1987;45:755–763.

    PubMed  CAS  Google Scholar 

  63. Aaron JE, Gallagher JC, Anderson J, et al. Frequency of osteomalacia and osteoporosis in fractures of the proximal femur. Lancet. 1974;1:229–233.

    Article  PubMed  CAS  Google Scholar 

  64. Sowers MR, Wallace RB, Hollis BBW, Lemke JH. Parameters related to 25-OH-D levels in a population-based study of women. Am J Clin Nutr. 1986;43:621–628.

    PubMed  CAS  Google Scholar 

  65. Delvin EE, Imbach A, Copti M. Vitamin D nutritional status and related biochemical indices in an autonomous elderly population. Am J Clin Nutr. 1988;48:373–378.

    PubMed  CAS  Google Scholar 

  66. Gibson RS, Draper HH, McGirr LG, et al. The vitamin D status of a cohort of postmenopausal non-institutionalized Canadian women. Nutri Research. 1986;6:1179–1187.

    Article  CAS  Google Scholar 

  67. Reid IR, Gallagher DJA, Bosworth J. Prophylaxis against vitamin D deficiency in the elderly by regular sunlight exposure. Age Ageing. 1986;15:35–40.

    Article  PubMed  CAS  Google Scholar 

  68. Lips P, Van Ginkel FC, Jongen MJM, et al. Determinants of vitamin D status in patients with hip fracture and in elderly control subjects. Am J Clin Nutr. 1987;46:1005–10.

    PubMed  CAS  Google Scholar 

  69. Egsmose C, Lund B, McNair P, et al. Low serum levels of 25-hydroxyvitamin D and1,25 dihydroxyvitamin D in institutionalized old people: influence of solar exposure and vitamin D supplementation. Age & Ageing. 1987;16:35–40.

    Article  CAS  Google Scholar 

  70. Jones G, Byrnes B, Duthie D, Jeejeebhoy KN. Contribution of skin vitamin D3 synthesis in patients receiving total parenteral nutrition. In: Norman AW, Schaefer K, Herrath DV, et al., eds. Vitamin D: Basic Research and Its Clinical Application. Berlin: Walter de Gruyter; 1979:169–172.

    Google Scholar 

  71. Anderson J, Campbell AER, Dunn A, Runciman JBM. Osteomalacia in elderly women. Scot Med J. 1966;82:429–435.

    Google Scholar 

  72. Chalmers J, Conacher WDH, Gardner DL, Scott PJ. Osteomalacia-a common disease in elderly women. J Bone Joint Surg. 1976; 49B:403–423.

    Google Scholar 

  73. Webster SGP, Leeming JT, Wilkinson EM. The causes of osteomalacia in the elderly. Age Aging. 1976;5:119–122.

    Article  CAS  Google Scholar 

  74. Meredith SC, Rosenberg IH. Gastrointestinal- hepatic disorders and osteomalacia. Clin Endocrinol Metab. 1980;9:131–150.

    Article  PubMed  CAS  Google Scholar 

  75. Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med. 1992; 327:1637–1642.

    Article  PubMed  CAS  Google Scholar 

  76. Lips P, Wiersinga A, Van Ginkel FC, et al. The effect of vitamin D supplementation on vita min D status and parathyroid function in elderly subjects. J Clin Endocrin & Metab. 1988;67:644–649.

    Article  CAS  Google Scholar 

  77. Dawson-Hughes B, Dallal GE, Krall EA, Sa sowski L, Sahyoun N, Tannenbaum S. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. New Eng J Med. 1990;323:878–883.

    Article  PubMed  CAS  Google Scholar 

  78. Burnell JM, Baylink DJ, Chestnut CH, Teubner EJ. The role of skeletal calcium deficiency in postmenopausal osteoporosis. Calcif Tissue Int. 1986;38:187–192.

    Article  PubMed  CAS  Google Scholar 

  79. Corless D, Dawson E, Fraser F, Ellis M. Do vitamin D supplements improve the physical capabilities of elderly hospital patients? Age Ageing. 1985;14:76–84.

    Article  PubMed  CAS  Google Scholar 

  80. Krolner B, Nielsen SP, Lund B, Lund BJ, Sorensen OH, Jacobsen S. Lumar spine bone mineral content in post-menopausal osteoporosis. (Abstract) Calcif Tissue Int. 1980;31S: 77A.

    Google Scholar 

  81. Shiraki M, Orimo H, Ito H, et al. Long-term treatment of postmenopausal osteoporosis with active vitamin D3 1-alphahydroxychole calciferol and 1,24-dihydroxycholecalciferol. Endocrinol Jpn. 1985;32:305–315.

    Article  PubMed  CAS  Google Scholar 

  82. Aloia JF, Vaswani A, Yeh J, Ellis K, Yasumura S, Cohn S. Calcitriol in the treatmentof postmenopausal osteoporosis. Am J Med.1988;84:401–408.

    Article  PubMed  CAS  Google Scholar 

  83. Shiraki M, Orimo H, Ito H, Akiguchi I, Nakao J, Takahashi R. Long-term treatment of postmenopausal osteoporosis with active vitamin D3, 1-alpha-hydroxycholecalciferol (1-OHD3) and 1,24-dihydroxycholecalciferol(1,24(OH)2D3). Endocrinol Jpn. 1985;32:305–315.

    CAS  Google Scholar 

  84. Gallagher JC, Goldgar D. Treatment of postmenopausal osteoporosis with high doses of synthetic calcitriol. Ann Intern Med. 1990; 113:649–655.

    PubMed  CAS  Google Scholar 

  85. Ott SM, Chestnut CH. Calcitriol treatment is not effective in postmenopausal osteoporosis. Ann Intern Med. 1989;110:267–274.

    PubMed  CAS  Google Scholar 

  86. Tilyard M. 1,25 dihydroxyvitamin D3 versus calcium in the treatment of established postmenopausal osteoporosis. J Bone Min Res. 5(S2) 1990.

    Google Scholar 

  87. Johnston CC, Miller JZ, Slemenda CW, et al. Calcium supplementation and increases in bone mineral density in children. N Engl J Med. 1992:327:82–87.

    Article  PubMed  Google Scholar 

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Authors
  1. J. C. Gallagher
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  2. Anne Fillion
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Université de Montréal, Hôpital du Sacré-Coeur de Montréal, H4J 1C5, Montréal, Quebec, Canada

    Jacques Lorrain M.D., FRCS(C), FACOG (Clinical Professor, Director) (Clinical Professor, Director)

  2. Gynecological Endocrinology and Reproductive Medicine, Hôpital du Sacré-Coeur de Montréal, H4J 1C5, Montréal, Quebec, Canada

    Jacques Lorrain M.D., FRCS(C), FACOG (Clinical Professor, Director) (Clinical Professor, Director)

  3. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics-Gynecology, Medical College of Georgia, 30912-3360, Augusta, GA, USA

    Leo Plouffe Jr. M.D. (Associate Professor/Director of Clinical Services) (Associate Professor/Director of Clinical Services)

  4. University of Massachusetts Medical Center, 01655, Worcester, MA, USA

    Veronica A. Ravnikar M.D. (Professor of Obstetrics and Gynecology, Director of Reproductive Endocrinology, Fertility, Menopause) (Professor of Obstetrics and Gynecology, Director of Reproductive Endocrinology, Fertility, Menopause)

  5. Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health Sciences University School of Medicine, 97201-3098, Portland, OR, USA

    Leon Speroff M.D. (Professor and Chairman) (Professor and Chairman)

  6. Division of Endocrinology, Department of Medicine, The Emory University School of Medicine, 30322, Atlanta, GA, USA

    Nelson B. Watts M.D. (Associate Professor) (Associate Professor)

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Gallagher, J.C., Fillion, A. (1994). Calcium and Vitamin D . In: Lorrain, J., Plouffe, L., Ravnikar, V.A., Speroff, L., Watts, N.B. (eds) Comprehensive Management of Menopause. Clinical Perspectives in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4330-4_14

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  • DOI: https://doi.org/10.1007/978-1-4612-4330-4_14

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8737-7

  • Online ISBN: 978-1-4612-4330-4

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