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Isolated Heart Models

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Cardiac Electrophysiology Methods and Models

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Abstract

Cardiovascular research employs a milieu of experimental models to investigate various conditions of health and disease ranging from cellular and whole organ preparations to computer modeling simulations. Uniquely, the isolated perfused heart model allows for the separation of cardiac and systemic variables, yet one can still explore typical measures used in cardiac research including myocardial function, metabolism, and/or responses to pharmacological, mechanical, and electrical components. A survey of the literature reveals that such preparations can vary greatly in design including choice of animal model, perfusion modes, perfusate compositions, and/or procedural techniques. Further, the wide array of measurements are made in the denervated heart, allowing one to conduct research in the absence of the confounding effects of sympathetic and vagal stimulations. Recently, there have been several groups employing high-resolution imaging and monitoring technologies to gain further insight into the intracardiac environment and/or the impact of various surgical procedures and implant techniques on the device–tissue interface. This chapter summarizes the major methodologies used to support these models, provides examples of usage, and clarifies the advantages and disadvantages of isolated hearts in comparison with other types of cardiovascular research.

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Author information

Authors and Affiliations

  1. Medtronic, Inc., Mounds View, MN, USA

    Nicholas D. Skadsberg

Authors
  1. Nicholas D. Skadsberg
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  2. Alexander J. Hill
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  3. Paul A. Iaizzo
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Corresponding author

Correspondence to Nicholas D. Skadsberg .

Editor information

Editors and Affiliations

  1. Dept. Integrative Biology and Physiolgy, 6-125 Jackson Hall, University of Minnesota, 321 Church Street SE., Minneapolis, 55455, Minnesota, USA

    Daniel C. Sigg

  2. Department of Surgery, B172 Mayo, MMC 107, University of Minnesota, 420 Delaware Street SE., Minneapolis, 55455, Minnesota, USA

    Paul A. Iaizzo

  3. Cardiac Rhythm Disease, Management (CRDM), Medtronic, Inc., 8200 Coral Sea Street NE.,, Mounds View, 55112, Minnesota, USA

    Yong-Fu **ao

  4. Deptarment of Biomedical Engineering, 7-105 Hasselmo Hall, University of Minnesota, 312 Church Street SE., Minneapolis, 55455, Minnesota, USA

    Bin He

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Skadsberg, N.D., Hill, A.J., Iaizzo, P.A. (2010). Isolated Heart Models. In: Sigg, D., Iaizzo, P., **ao, YF., He, B. (eds) Cardiac Electrophysiology Methods and Models. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6658-2_12

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  • DOI: https://doi.org/10.1007/978-1-4419-6658-2_12

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  • Online ISBN: 978-1-4419-6658-2

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