Abstract
We have described the in vitro mutagenicity of benzidine (BZD) and 4,4″-diaminoterphenyl (DAT) indicating that acetylation may be more critical for generating the active mutagenic metabolites for BZD than for DAT (Paes et al., this volume). Dog liver S9 preparations are known to be devoid of acetylase enzymes (Lower and Bryan, 1973). In this communication we have attempted to determine the role of acetylation in the activation of these two mutagens by using uninduced dog liver S9 in addition to uninduced rat liver S9. The effect of supplementation with acetyl CoA or co-incubation with iodoacetate was also investigated.
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© 1985 United Kingdom Environmental Mutagen Society
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Paes, D., Gatehouse, D., Tweats, D., Holtby, Y. (1985). The in vitro Mutagenicity of Benzidine and 4,4″-Diaminoterphenyl. In: Parry, J.M., Arlett, C.F. (eds) Comparative Genetic Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07901-8_18
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DOI: https://doi.org/10.1007/978-1-349-07901-8_18
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