Abstract
Acute myocardial infarction continues to account for a growing burden of heart failure worldwide. Despite existing therapies, new approaches for reducing the extent of damage and better managing heart failure progression are urgently needed. Preclinical large animal models are a critical step in the translation of scientific discoveries toward clinical trials and therapeutic application. In this chapter, we detail methods to induce swine models of myocardial infarction through catheter-mediated approaches involving either temporary (ischemia-reperfusion) or permanent (thrombus injection or embolic coil) occlusions. These techniques are relatively low in invasiveness, while infarct size with corresponding cardiac dysfunction can be controlled by adjusting the location of coronary occlusion. We also describe methods for cardiac angiography and echocardiography in pigs. This is the second edition of a previously published chapter with modifications.
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Acknowledgments
This work was supported by National Institutes of Health R01HL139963 (to K.I.). We would like to acknowledge the equipment funding from NIH for the C-arm (S10OD034330).
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Mazurek, R., Bikou, O., Ishikawa, K. (2024). Swine Model of Myocardial Infarction Induced by Ischemia-Reperfusion and Embolization. In: Ishikawa, K. (eds) Experimental Models of Cardiovascular Diseases. Methods in Molecular Biology, vol 2803. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3846-0_14
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DOI: https://doi.org/10.1007/978-1-0716-3846-0_14
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