Abstract
Cerebral ischemia produces a decrease, loss, or instability of the assembly processes in the neuronal cytoskeleton, related to the alteration in the normal processes of phosphorylation of the Tau protein, triggering its hyperphosphorylation and altering the normal processes of formation of neuronal microtubules. Here we describe the methods used to study the impact of middle cerebral artery occlusion (MCAo) on neurological functions and Tau phosphorylation in Wistar rat brain.
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Acknowledgments
This work was supported by the Universidad Icesi and the Colombian Administrative Department of Science, Technology and Innovation (Colciencias) grants contracts No. 244-2010 and No.616-2014.
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Vera-González, A., Cardozo, C.F., Araque, E.V., Cruz, M.J., Arango-Davila, C.A., Rengifo-Gómez, J. (2024). A Brain Ischemia-Reperfusion Model for the Study of Tau Phosphorylation and O-GlcNAcylation. In: Smet-Nocca, C. (eds) Tau Protein. Methods in Molecular Biology, vol 2754. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3629-9_34
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DOI: https://doi.org/10.1007/978-1-0716-3629-9_34
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