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Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation

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Nipah Virus

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2682))

Abstract

Hendra and Nipah viruses are henipaviruses that have caused lethal human disease in Australia and Malaysia, Bangladesh, India, and the Philippines, respectively. These viruses are considered Category C pathogens by the US Centers for Disease Control. Nipah virus was recently placed on the World Health Organization Research and Development Blueprint Roadmaps for vaccine and therapeutic development. Given the infrequent and unpredictable nature of henipavirus outbreaks licensure of vaccines and therapeutics will likely require an animal model to demonstrate protective efficacy against henipavirus disease. Studies have shown that nonhuman primates are the most accurate model of human henipavirus disease and would be an important component of any application for licensure of a vaccine or antiviral drug under the US FDA Animal Rule. Nonhuman primate model selection and dosing are discussed regarding vaccine and therapeutic studies against henipaviruses.

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Author information

Authors and Affiliations

  1. Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA

    Chad E. Mire & Thomas W. Geisbert

  2. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA

    Chad E. Mire & Thomas W. Geisbert

  3. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA

    Benjamin A. Satterfield

  4. National Bio- and Agro-defense Facility, Agricultural Research Services, United States Department of Agriculutre, Manhattan, NY, USA

    Chad E. Mire

Authors
  1. Chad E. Mire
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  2. Benjamin A. Satterfield
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  3. Thomas W. Geisbert
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Corresponding author

Correspondence to Chad E. Mire .

Editor information

Editors and Affiliations

  1. Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA

    Alexander N. Freiberg

  2. Wageningen Bioveterinary Institute, Lelystad and Department of Viroscience, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

    Barry Rockx

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Mire, C.E., Satterfield, B.A., Geisbert, T.W. (2023). Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation. In: Freiberg, A.N., Rockx, B. (eds) Nipah Virus. Methods in Molecular Biology, vol 2682. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3283-3_12

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  • DOI: https://doi.org/10.1007/978-1-0716-3283-3_12

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3282-6

  • Online ISBN: 978-1-0716-3283-3

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