Abstract
There are numerous methods described for the identification and quantification of organophosphorus insecticides, and these involve sample preparation techniques such as solid-phase or liquid–liquid extraction. However, the demand for more efficient and productive approaches by laboratories continues to increase. As an improvement over the existing procedures, we describe herein a new method for the determination of five organophosphorus insecticides (diazinon, chlorpyrifos, parathion-ethyl, chlorfenvinphos, and quinalphos) in low volume urine specimens, using the dried urine spots (DUS) sampling approach and gas chromatography (GC) coupled to tandem mass spectrometry (MS/MS) analysis. The studied compounds were chosen for their incidence in intoxications, and ethion was used as internal standard. The novelty of using the DUS approach for the extraction of these compounds guarantees greater simplicity and sensitivity compared to conventional extraction techniques and can be applied routinely in scenarios of clinical and forensic toxicology.
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Soares, S., Pinto, I., Barroso, M., Gallardo, E. (2022). Dried Urine Spots as a Sampling Approach for the Determination of Organophosphorus Insecticides by Gas Chromatography Tandem Mass Spectrometry. In: Gallardo, E., Barroso, M. (eds) Pesticide Toxicology. Methods in Pharmacology and Toxicology. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1928-5_10
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DOI: https://doi.org/10.1007/978-1-0716-1928-5_10
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