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Electron Attachment to Isolated Molecules as a Probe to Understand Mitochondrial Reductive Processes

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Mitochondrial Medicine

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2277))

Abstract

This chapter describes the complementary experimental techniques Electron Transmission Spectroscopy and Dissociative Electron Attachment Spectroscopy, two of the most suitable means for investigating interactions between electrons and gas-phase molecules, resonance formation of temporary molecular negative ions, and their possible decay through the dissociative electron attachment (DEA) mechanism. The latter can be seen as the gas-phase counterpart of the transfer of a solvated electron in solution, accompanied by dissociation of the molecular anion, referred to as dissociative electron transfer (DET). DET takes place in vivo under reductive conditions, for instance, in the intermembrane space of mitochondria under interaction of xenobiotic molecules possessing high electron affinity with electrons “leaked” from the mitochondrial respiratory chain. A likely mechanism of the toxic activity of dichlorodiphenyltrichloroethane based on its DEA properties is briefly outlined, and compared with the well-established harmful effects of the model toxicant carbon tetrachloride ascribed to reductive dechlorination in a cellular ambient. A possible mechanism of the antioxidant activity of polyphenolic compounds present near the main site of superoxide anion production in mitochondria is also briefly discussed.

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Acknowledgements

Thanks are due to the Russian Foundation for Basic Research (grant #18-03-00179) and the Italian Ministero dell’Istruzione, dell’Università e della Ricerca for financial support.

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Authors and Affiliations

  1. Institute of Molecule and Crystal Physics, Ufa Federal Research Centre, Russian Academy of Sciences, Ufa, Russia

    Stanislav A. Pshenichnyuk

  2. Dipartimento di Chimica “G. Ciamician”, Università di Bologna, Bologna, Italy

    Alberto Modelli

  3. Centro Interdipartimentale di Ricerca in Scienze Ambientali, Ravenna, Italy

    Alberto Modelli

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  1. Stanislav A. Pshenichnyuk
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  2. Alberto Modelli
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Correspondence to Stanislav A. Pshenichnyuk .

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Editors and Affiliations

  1. Department of Pharmaceutical Sciences, Midwestern University, Glendale, AZ, USA

    Volkmar Weissig

  2. Cochin Hospital, Cochin Institute, INSERM U1016, PARIS, France

    Marvin Edeas

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Pshenichnyuk, S.A., Modelli, A. (2021). Electron Attachment to Isolated Molecules as a Probe to Understand Mitochondrial Reductive Processes. In: Weissig, V., Edeas, M. (eds) Mitochondrial Medicine. Methods in Molecular Biology, vol 2277. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1270-5_7

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  • DOI: https://doi.org/10.1007/978-1-0716-1270-5_7

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