Abstract
Cognitive impairment affects up to 70% of patients with multiple sclerosis (MS). It may already be present in the early stages of disease and impedes with a patient’s ability to maintain employment, take part in activities of daily life, and fully participate in society. Similar to the clinical heterogeneity of MS , there is great variability in cognitive symptoms among patients. Given the impact of such deficits on everyday functioning, an increasing interest in diagnosis and treatment of cognitive impairment has arisen.
This chapter aims to present an overview of those cognitive domains most commonly affected in MS , common approaches to assess the respective cognitive functions as well as procedures which may facilitate cross-species study of cognition.
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References
Amato MP, Ponziani G, Pracucci G, Bracco L, Siracusa G, Amaducci L (1995) Cognitive impairment in early-onset multiple sclerosis: pattern, predictors, and impact on everyday life in a 4-year follow-up. Arch Neurol 52(2):168–172
Benedict RHB, Wahlig E, Bakshi R, Fishman I, Munschauer F, Zivadinov R, Weinstock-Guttman B (2005) Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change. J Neurol Sci 231(1–2):29–34
Goverover Y, Chiaravalloti N, DeLuca J (2015) Brief international cognitive assessment for multiple sclerosis (BICAMS) and performance of everyday life tasks: actual reality. Mult Scler J 22(4):544–550
Morrow SA, Drake A, Zivadinov R, Munschauer F, Weinstock-Guttman B, Benedict RHB (2010) Predicting loss of employment over three years in multiple sclerosis: clinically meaningful cognitive decline. Clin Neuropsychol 24(7):1131–1145
Raggi A, Covelli V, Schiavolin S, Scaratti C, Leonardi M, Willems M (2016) Work-related problems in multiple sclerosis: a literature review on its associates and determinants. Disabil Rehabil 38(10):936–944
Hoogs M, Kaur S, Smerbeck A, Weinstock-Guttman B, Benedict RHB (2011) Cognition and physical disability in predicting health-related quality of life in multiple sclerosis. Int J MS Care 13(2):57–63
Kalmar JH, Gaudino EA, Moore NB, Halper J, DeLuca J (2008) The relationship between cognitive deficits and everyday functional activities in multiple sclerosis. Neuropsychology 22(4):442–449
Lincoln NB, Radford KA (2008) Cognitive abilities as predictors of safety to drive in people with multiple sclerosis. Mult Scler J 14(1):123–128
Rao SM, Leo GJ, Bernardin L, Unverzagt F (1991) Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41(5):685–691
Larner AJ (2013) Neuropsychological neurology: the neurocognitive impairments of neurological disorders, 2nd edn. Cambridge University Press, Cambridge, U.K.
DeLuca GC, Yates RL, Beale H, Morrow SA (2015) Cognitive impairment in multiple sclerosis: clinical, radiologic and pathologic insights. Brain Pathol 25(1):79–98
James W (1890) Attention. In: The principles of psychology. Henry Holt and Company, New York, NY, USA, pp 402–458
Potagas C, Giogkaraki E, Koutsis G, Mandellos D, Tsirempolou E, Sfagos C, Vassilopoulos D (2008) Cognitive impairment in different MS subtypes and clinically isolated syndromes. J Neurol Sci 267(1–2):100–106
Nilsson PC, Rorsman I, Larsson EM, Norrving B, Sandberg-Wollheim M (2008) Cognitive dysfunction 24-31 years after isolated optic neuritis. Mult Scler 14(7):913–918
Huijbregts SCJ, Kalkers NF, de Sonneville LMJ, de Groot V, Polman CH (2006) Cognitive impairment and decline in different MS subtypes. J Neurol Sci 245(1–2):187–194
Smith A (1973) Symbol digit modalities test. Western Psychological Services, Los Angeles, CA
Strauss E, Sherman EM, Spreen O (2006) A compendium of neuropsychological tests: administration, norms, and commentary. American Chemical Society, Washington, D.C.
Benedict RH, DeLuca J, Phillips G, LaRocca N, Hudson LD, Rudick R, Multiple Sclerosis Outcome Assessments Consortium (2017) Validity of the symbol digit modalities test as a cognition performance outcome measure for multiple sclerosis. Mult Scler 23(5):721–733
Reitan RM, Wolfson D (1985) The Halstead Reitan neuropsychological test battery: theory and clinical interpretation. Neuropsychology Press, Tucson, AZ
Schulz D, Kopp B, Kunkel A, Faiss JH (2006) Cognition in the early stage of multiple sclerosis. J Neurol 253(8):1002–1010
Rao SM (1986) Neuropsychology of multiple sclerosis: a critical review. J Clin Exp Neuropsychol 8(5):503–542
Rao SM, Leo GJ, St. Aubin-Faubert P (1989) On the nature of memory disturbance in multiple sclerosis. J Clin Exp Neuropsychol 11(5):699–712
Kocer B, Unal T, Nazliel B (2008) Evaluating sub-clinical cognitive dysfunction and event-related potentials (P300) in clinically isolated syndrome. Neurol Sci 29(6):435–444
Thornton AE, Raz N, Tucker KA (2002) Memory in multiple sclerosis: contextual encoding deficits. J Int Neuropsychol Soc 8(3):395–409
DeLuca J, Gaudino EA, Diamond BJ, Christodoulou C, Engel RA (1998) Acquisition and storage deficits in multiple sclerosis. J Clin Exp Neuropsychol 20(3):376–390
Feinstein A, Kartsounis LD, Miller DH, Youl BD, Ron MA (1992) Clinically isolated lesions of the type seen in multiple sclerosis: a cognitive, psychiatric, and MRI follow up study. J Neurol Neurosurg Psychiatry 55(10):869–876
Glanz BI, Holland CM, Gauthier SA, Amunwa EL, Liptak Z, Houtchens MK et al (2007) Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler J 13(8):1004–1010
Rey A (1964) L ‘examen clinique en psychologie. Presses Universitaires de France, Paris
Schmidt M (1996) Rey auditory verbal learning test: a handbook. Western Psychological Services, Los Angeles, CA
MĂ¼ller H, Hasse-Sander I, Horn R, Helmstädter C, Elger CE (1997) Rey auditory verbal learning test: structure of a modified German version. J Clin Psychol 53(7):663–671
Miranda JP, Valencia RR (1997) English and Spanish versions of a memory test: word-length effects versus spoken duration effects. Hisp J Behav Sci 19(2):171–181
Lee TMC (2003) Normative data: neuropsychological measures for Hong Kong Chinese. Neuropsychology Laboratory, The University of Hong Kong, Hong Kong
Wechsler D (2009) Wechsler memory scale—fourth edition (WMS–IV) technical and interpretive manual. Pearson, San Antonio, TX
Feuillet L, Reuter F, Audoin B, Malikova I, Barrau K, Cherif AA, Pelletier J (2007) Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis. Mult Scler J 13(1):124–127
Leavitt VM, Wylie G, Krch D, Chiaravalloti N, DeLuca J, Sumowski JF (2014) Does slowed processing speed account for executive deficits in multiple sclerosis? Evidence from neuropsychological performance and structural neuroimaging. Rehabil Psychol 59(4):422–428
Anhoque CF, Biccas Neto L, Domingues SCA, Teixeira AL, Domingues RB (2012) Cognitive impairment in patients with clinically isolated syndrome. Dement Neuropsychol 6(4):266–269
Henry JD, Beatty WW (2006) Verbal fluency deficits in multiple sclerosis. Neuropsychologia 44(7):1166–1174
Huijbregts SCJ, Kalkers NF, de Sonneville LMJ, de Groot V, Reuling IEW, Polman CH (2004) Differences in cognitive impairment of relapsing remitting, secondary, and primary progressive MS. Neurology 63(2):335–339
Gronwall DM (1977) Paced auditory serial-addition task: a measure of recovery from concussion. Percept Mot Skills 44(2):367–373
Cutter GR, Baier ML, Rudick RA, Cookfair DL, Fischer JS, Petkau J, Ellison GW (1999) Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain 122(5):871–882
Rao SM (1990) Neuropsychological screening battery for multiple sclerosis. National Multiple Sclerosis Society, New York, NY, USA
Aschenbrenner S, Tucha O, Lange KW (2001) Regensburger WortflĂ¼ssigkeits-Test. Hogrefe, Göttingen
Artiola L, Hermisollo D, Heaton R, Pardee RE (1999) Manual de normas y procedimientos para la baterĂa neuropsicolĂ³gica en español [manual of norms and procedures for the Spanish neuropsychological battery]. m Press, Tucson, AZ
Vleugels L, Lafosse C, van Nunen AN, Nachtergaele S, Ketelaer P, Charlier M, Vandenbussche E (2000) Visuoperceptual impairment in multiple sclerosis patients diagnosed with neuropsychological tasks. Mult Scler 6(4):241–254
Barnes CA (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 93(1):74–104
Rosenfeld CS, Ferguson SA (2014) Barnes maze testing strategies with small and large rodent models. J Vis Exp 84:e51194
Harrison FE, Reiserer RS, Tomarken AJ, McDonald MP (2006) Spatial and nonspatial escape strategies in the Barnes maze. Learn Mem 13(6):809–819
Paul CM, Magda G, Abel S (2009) Spatial memory: theoretical basis and comparative review on experimental methods in rodents. Behav Brain Res 203(2):151–164
Holtzman DA, Harris TW, Aranguren G, Bostock E (1999) Spatial learning of an escape task by young corn snakes, Elaphe guttata guttata. Anim Behav 57(1):51–60
Brown S, Strausfeld N (2009) The effect of age on a visual learning task in the American cockroach. Learn Mem 16(3):210–223
Languille S, Aujard F, Pifferi F (2012) Effect of dietary fish oil supplementation on the exploratory activity, emotional status and spatial memory of the aged mouse lemur, a non-human primate. Behav Brain Res 235(2):280–286
Hollinger KR, Alt J, Riehm AM, Slusher BS, Kaplin AI (2016) Dose-dependent inhibition of GCPII to prevent and treat cognitive impairment in the EAE model of multiple sclerosis. Brain Res 1635:105–112
CANTAB® [Cognitive assessment software]. Cambridge Cognition (2019). All rights reserved. www.cantab.com
Weed MR, Taffe MA, Polis I, Roberts AC, Robbins TW, Koob GF et al (1999) Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance. Cogn Brain Res 8(3):185–201
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Person, M., Becke, M. (2021). Translational Research in Neuroimmunology: Cognition. In: Groppa, S., G. Meuth, S. (eds) Translational Methods for Multiple Sclerosis Research. Neuromethods, vol 166. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1213-2_12
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DOI: https://doi.org/10.1007/978-1-0716-1213-2_12
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