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Synthesis of Heterocycles via Microwave-Assisted Cycloadditions and Cyclocondensations

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Microwave-Assisted Synthesis of Heterocycles

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 1))

Abstract

Controlled microwave heating has found many important applications in the synthesis of heterocycles. Almost all kinds of heterocycles have been prepared (or their preparation attempted) with the aid of microwaves. Many examples of cyclocondensations, reactions where two or more functional groups combine with the loss of another small molecule (usually water), have been described. Moreover, microwave irradiation successfully induces cycloaddition reactions, especially in the cases where high temperatures are required. This review collects the most representative examples of the application of microwaves to these two kinds of transformations. Except for a few examples, all the reactions selected have been carried out under controlled microwave irradiation using dedicated instruments.

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Authors and Affiliations

  1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 86, Fisciano, Italy

    Manuela Rodriquez

  2. Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy

    Maurizio Taddei

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  1. Manuela Rodriquez
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  2. Maurizio Taddei
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Correspondence to Maurizio Taddei .

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Erik Van der Eycken C. Oliver Kappe

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Rodriquez, M., Taddei, M. Synthesis of Heterocycles via Microwave-Assisted Cycloadditions and Cyclocondensations. In: Van der Eycken, E., Kappe, C.O. (eds) Microwave-Assisted Synthesis of Heterocycles. Topics in Heterocyclic Chemistry, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_005

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