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Molecular Mechanisms of Energy Transduction in Cells: Engineering Applications and Biological Implications

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Biotechnology in India II

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 85))

Abstract

The synthesis of ATP from ADP and inorganic phosphate by F1F0-ATP synthase, the universal enzyme in biological energy conversion, using the energy of a transmembrane gradient of ions, and the use of ATP by the myosin-actin system to cause muscular contraction are among the most fundamental processes in biology. Both the ATP synthase and the myosin-actin may be looked upon as molecular machines. A detailed analysis of the molecular mechanisms of energy transduction by these molecular machines has been carried out in order to understand the means by which living cells produce and consume energy. These mechanisms have been compared with each other and their biological implications have been discussed. The thermodynamics of energy coupling in the oxidative phosphorylation process has been developed and the consistency of the mechanisms with the thermodynamics has been explored. Novel engineering applications that can result have been discussed in detail and several directions for future work have been pointed out.

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Author information

Authors and Affiliations

  1. Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi, 110 016, India

    Sunil Nath

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  1. Sunil Nath
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Editors and Affiliations

  1. 281 SFS Apartments, Hauz Khas, New Delhi, 110 016, India

    Tarun K. Ghose

  2. Birla Institute of Scientific Research, Statue Circle, Jaipur, 302 001, India

    Purnendu Ghosh

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Dedicated to Prof. Tarun K. Ghose on the occasion of his 78th birthday

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Nath, S. (2003). Molecular Mechanisms of Energy Transduction in Cells: Engineering Applications and Biological Implications. In: Ghose, T.K., et al. Biotechnology in India II. Advances in Biochemical Engineering/Biotechnology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36466-8_5

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  • DOI: https://doi.org/10.1007/3-540-36466-8_5

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-00563-6

  • Online ISBN: 978-3-540-36466-5

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