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Applications of Metallic Nanoparticles in Lung Cancer Treatment

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Interdisciplinary Cancer Research

Part of the book series: Interdisciplinary Cancer Research

Abstract

With approximately 1.8 million deaths in 2020, lung cancer remains the leading cause of cancer death globally, contributing 18% to the total cancer deaths. Various treatment choices are followed for lung cancer, including surgery, radiation therapy, chemotherapy and targeted therapy. Therapeutic modality recommendations rely on many factors, such as the type and stage of cancer. Despite many developments in diagnosis and therapy made during previous years, the prognosis for patients with lung cancer is still dissatisfying. In recent years, the possible implementations of nanotechnology in diagnostics and therapeutic methods in clinical practice have noticeably changed, becoming exceptionally wide-ranging. Nanotechnology-based agents treat numerous human ailments, from degenerative to contagious diseases, specifically cancer. Different types of metallic nanoparticles have been developed, depicted by a favourable risk/reward ratio that leads to their introduction in clinical trials. Nanomedicine is a modern clinical medicine discipline that merges high specificity and selectivity in targeting tumour cells and low toxicity. Furthermore, in this discipline, metallic nanoparticles appear as attractive elements. In this chapter, recent metallic nanoparticles-based therapeutic agents developed are reviewed, with a specific focus on the possible implementations in clinical practice as anti-lung cancer agents, aiming their implementation to pave the way for a new golden era in oncology and a breakthrough in the battle against all types of cancers.

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References

  • ACS (2017) About lung cancer. https://www.cancer.org/content/dam/CRC/PDF/Public/8703.00.pdf. Accessed 8-5-2022

  • Alexis F, Rhee JW, Richie JP, Radovic-Moreno AF, Langer R, Farokhzad OC (2008) New frontiers in nanotechnology for cancer treatment. Urol Oncol 26(1):74–85

    Google Scholar 

  • Almatroudi A (2020) Silver nanoparticles: synthesis, characterisation and biomedical applications. Open Life Sci 15(1):819–839

    Google Scholar 

  • Almeida JP, Lin AY, Langsner RJ, Eckels P, Foster AE, Drezek RA (2014) In vivo immune cell distribution of gold nanoparticles in naïve and tumor bearing mice. Small 10(4):812–819

    Google Scholar 

  • AshaRani PV, Hande MP, Valiyaveettil S (2009a) Anti-proliferative activity of silver nanoparticles. BMC Cell Biol 10:65

    Google Scholar 

  • AshaRani PV, Low Kah Mun G, Hande MP, Valiyaveettil S (2009b) Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3(2):279–290

    Google Scholar 

  • Asomaning K, Miller DP, Liu G, Wain JC, Lynch TJ, Su L, Christiani DC (2008) Second hand smoke, age of exposure and lung cancer risk. Lung Cancer 16(1):13–20

    Google Scholar 

  • Brown SD, Nativo P, Smith JA, Stirling D, Edwards PR, Venugopal B, Flint DJ, Plumb JA, Graham D, Wheate NJ (2010) Gold nanoparticles for the improved anti-cancer drug delivery of the active component of oxaliplatin. J Am Chem Soc 132(13):4678–4684

    Google Scholar 

  • Carrasco-Esteban E, Domínguez-Rullán JA, Barrionuevo-Castillo P, Pelari-Mici L, Leaman O, Sastre-Gallego S, López-Campos F (2021) Current role of nanoparticles in the treatment of lung cancer. J Clin Transl Res 7(2):140–155

    Google Scholar 

  • Castro-Aceituno V, Ahn S, Simu SY, Singh P, Mathiyalagan R, Lee HA, Yang DC (2016) Anticancer activity of silver nanoparticles from Panax ginseng fresh leaves in human cancer cells. Biomed Pharmacother 84:158–165

    Google Scholar 

  • Cersosimo RJ (2002) Lung cancer: a review. Am J Health Syst Pharm 59:611–642

    Google Scholar 

  • Chang YS, Savitha S, Sadhasivam S, Hsu CK, Lin FH (2011) Fabrication, characterisation, and application of greigite nanoparticles for cancer hyperthermia. J Colloid Interface Sci 363(1):314–319

    Google Scholar 

  • Chen YH, Tsai CY, Huang PY, Chang MY, Cheng PC, Chou CH, Chen DH, Wang CR, Shiau AL, Wu CL (2007) Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol Pharm 4(5):713–722

    Google Scholar 

  • Chow EK, Ho D (2013) Cancer nanomedicine: from drug delivery to imaging. Sci Transl Med 5(216):216rv4

    Google Scholar 

  • Chugh H, Sood D, Chandra I, Tomar V, Dhawan G, Chandra R (2018) Role of gold and silver nanoparticles in cancer nanomedicine. Artif Cells Nanomed Biotechnol 46(sup1):1210–1220

    Google Scholar 

  • Cryer AM, Chan C, Eftychidou A, Maksoudian C, Mahesh M, Tetley TD, Spivey AC, Thorley AJ (2019) Tyrosine kinase inhibitor gold nanoconjugates for the treatment of non-small cell lung cancer. ACS Appl Mater Interfaces 11(18):16336–16346

    Google Scholar 

  • De Jong WH, Borm PJ (2008) Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine 3(2):133–149

    Google Scholar 

  • Ferreccio C, Yuan Y, Calle J, Benítez H, Parra RL, Acevedo J, Smith AH, Liaw J, Steinmaus C (2013) Arsenic, tobacco smoke, and occupation: associations of multiple agents with lung and bladder cancer. Epidemiol 24(6):898–905

    Google Scholar 

  • Florence AT (2012) “Targeting” nanoparticles: the constraints of physical laws and physical barriers. J Control Release 164(2):115–124

    Google Scholar 

  • Foldbjerg R, Dang DA, Autrup H (2011) Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549. Arch Toxicol 85(7):743–750

    Google Scholar 

  • Gindy ME, Prud’homme RK (2009) Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy. Expert Opin Drug Deliv 6(8):865–878

    Google Scholar 

  • Guinart A, Perry HL, Wilton-Ely JDET, Tetley TD (2020) Gold nanomaterials in the management of lung cancer. Emerg Top Life Sci 4(6):627–643

    Google Scholar 

  • Gurunathan S, Lee KJ, Kalishwaralal K, Sheikpranbabu S, Vaidyanathan R, Eom SH (2009) Antiangiogenic properties of silver nanoparticles. Biomaterials 30(31):6341–6350

    Google Scholar 

  • Hartshorn CM, Russell LM, Grodzinski P (2019) NCI alliance for nanotechnology in cancer-catalysing research and translation towards novel cancer diagnostics and therapeutics. Wiley Interdiscip Rev Nanomed Nanobiotechnol 11(6):e1570

    Google Scholar 

  • Howington JA, Blum MG, Chang AC, Balekian AA, Murthy SC (2013) Treatment of stage I and II non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143(5 Suppl):e278S–e313S

    Google Scholar 

  • Hubaux R, Becker-Santos DD, Enfield KSS, Lam S, Lam WL, Martinez VD (2012) Arsenic, asbestos and radon: emerging players in lung tumorigenesis. Environ Health 11:89

    Google Scholar 

  • Jett JR, Schild SE, Kesler KA, Kalemkerian GP (2013) Treatment of small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143(5 Suppl):e400S–e419S

    Google Scholar 

  • Karponis D, Azzawi M, Seifalian A (2016) An arsenal of magnetic nanoparticles; perspectives in the treatment of cancer. Nanomedicine (Lond) 11(16):2215–2232

    Google Scholar 

  • Khan MI, Mohammad A, Patil G, Naqvi SA, Chauhan LK, Ahmad I (2012) Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles. Biomaterials 33(5):1477–1488

    Google Scholar 

  • Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, Marks JD, Benz CC, Park JW (2006) Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localisation but does increase internalisation in animal models. Cancer Res 66(13):6732–6740

    Google Scholar 

  • Latimer KM, Mott TF (2015) Lung cancer: diagnosis, treatment principles, and screening. Am Fam Physician 91(4):250–256

    Google Scholar 

  • Malik P, Mukherjee TK (2018) Recent advances in gold and silver nanoparticle based therapies for lung and breast cancers. Int J Pharm 553(1–2):483–509

    Google Scholar 

  • MHKSA (2019) Lung cancer. https://www.moh.gov.sa/en/awarenessplateform/ChronicDisease/Documents/Lung%20Cancer.pdf. Accessed 4-5-2022

  • Mohan A, Garg A, Gupta A, Sahu S, Choudhari C, Vashistha V, Ansari A, Pandey R, Bhalla AS, Madan K, Hadda V, Iyer H, Jain D, Kumar R, Mittal S, Tiwari P, Pandey RM, Guleria R (2020) Clinical profile of lung cancer in North India: a 10-years analysis. Lung India 37:190–197

    Google Scholar 

  • Mu L, Liu L, Niu R, Zhao B, Shi J, Li Y, Swanson M, Scheider W, Su J, Chang SC, Yu S, Zhang ZF (2013) Indoor air pollution and risk of lung cancer among Chinese female non-smokers. Cancer Causes Control 24(3):439–450

    Google Scholar 

  • Mukherjee S, Chowdhury D, Kotcherlakota R, Patra S, Bhadra MP, Sreedhar B, Patra CR (2014) Potential theranostics application of bio-synthesised silver nanoparticles (4-in-1 system). Theranostics 4(3):316–335

    Google Scholar 

  • Muthukumarasamyvel T, Rajendran G, SanthanaPanneer D, Kasthuri J, Kathiravan K, Rajendiran N (2017) Role of surface hydrophobicity of dicationic amphiphile-stabilized gold nanoparticles on A549 lung cancer cells. ACS Omega 2(7):3527–3538

    Google Scholar 

  • Nagalingam M, Kalpana VN, Rajeswari D, Panneerselvam A (2018) Biosynthesis, characterisation, and evaluation of bioactivities of leaf extract-mediated biocompatible gold nanoparticles from Alternanthera bettzickiana. Biotechnol Rep (Amst) 19:e00268

    Google Scholar 

  • Nazir S, Muhammad I, Mazhar K, Muazzam A (2011) Novel and cost-effective green synthesis of silver nanoparticles and their in vivo antitumor properties against human cancer cell lines. J Biosci Tech 2:425–430

    Google Scholar 

  • Park EJ, Yi J, Kim Y, Choi K, Park K (2010) Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism. Toxicol In Vitro 24(3):872–878

    Google Scholar 

  • Raji V, Pal K, Zaheer T, Kalarikkal N, Thomas S, de Souza FG, Si A (2020) Gold nanoparticles against respiratory diseases: oncogenic and viral pathogens review. Ther Deliv 11(8):521–534

    Google Scholar 

  • Ramalingam V, Varunkumar K, Ravikumar V, Rajaram R (2018) Target delivery of doxorubicin tethered with PVP stabilised gold nanoparticles for effective treatment of lung cancer. Sci Rep 8(1):3815

    Google Scholar 

  • Ramnath N, Dilling TJ, Harris LJ, Kim AW, Michaud GC, Balekian AA, Diekemper R, Detterbeck FC, Arenberg DA (2013) Treatment of stage III non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143(5 Suppl):e314S–e340S

    Google Scholar 

  • Sadhukha T, Wiedmann TS, Panyam J (2013) Inhalable magnetic nanoparticles for targeted hyperthermia in lung cancer therapy. Biomaterials 34(21):5163–5171

    Google Scholar 

  • Sankar R, Karthik A, Prabu A, Karthik S, Shivashangari KS, Ravikumar V (2013) Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anti-cancer activity. Colloids Surf B Biointerfaces 108:80–84

    Google Scholar 

  • Shi H, Ye X, He X, Wang K, Cui W, He D, Li D, Jia X (2014) Au@ag/au nanoparticles assembled with activatable aptamer probes as smart “nano-doctors” for image-guided cancer thermotherapy. Nanoscale 6(15):8754–8761

    Google Scholar 

  • Singh N, Agrawal S, Jiwnani S, Khosla D, Malik PS, Mohan A, Penumadu P, Prasad KT (2021) Lung cancer in India. J Thorac Oncol 16(8):1250–1266

    Google Scholar 

  • Sun B, Hu N, Han L, Pi Y, Gao Y, Chen K (2019) Anticancer activity of green synthesised gold nanoparticles from Marsdenia tenacissima inhibits A549 cell proliferation through the apoptotic pathway. Artif Cells Nanomed Biotechnol 47(1):4012–4019

    Google Scholar 

  • Sun M, Wang T, Li L, Li X, Zhai Y, Zhang J, Li W (2021) The application of inorganic nanoparticles in molecular targeted cancer therapy: EGFR targeting. Front Pharmacol 12:702445

    Google Scholar 

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249

    Google Scholar 

  • Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363(8):733–742

    Google Scholar 

  • Tiloke C, Phulukdaree A, Anand K, Gengan RM, Chuturgoon AA (2016) Moringa oleifera gold nanoparticles modulate oncogenes, tumor suppressor genes, and Caspase-9 splice variants in A549 cells. J Cell Biochem 117(10):2302–2314

    Google Scholar 

  • Turner MC, Andersen ZJ, Baccarelli A, Diver WR, Gapstur SM, Pope CA, Prada D, Samet J, Thurston G, Cohen A (2020) Outdoor air pollution and cancer: an overview of the current evidence and public health recommendations. CA Cancer J Clin 70:460–479

    Google Scholar 

  • Wang MS, Chen L, **ong YQ, Xu J, Wang JP, Meng ZL (2017) Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner. Int J Nanomedicine 12:7627–7651

    Google Scholar 

  • Wang Y, Xu J, Shi L, Yang H (2020) Recent advances in the antilung cancer activity of biosynthesised gold nanoparticles. J Cell Physiol 235(12):8951–8957

    Google Scholar 

  • Woodman C, Vundu G, George A, Wilson CM (2021) Applications and strategies in nanodiagnosis and nanotherapy in lung cancer. Semin Cancer Biol 69:349–364

    Google Scholar 

  • Yokoyama T, Tam J, Kuroda S, Scott AW, Aaron J, Larson T, Shanker M, Correa AM, Kondo S, Roth JA, Sokolov K, Ramesh R (2011) EGFR-targeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cells. PLoS One 6(11):e25507

    Google Scholar 

  • Yu H, Wang Y, Wang S, Li X, Li W, Ding D, Gong X, Keidar M, Zhang W (2018) Paclitaxel-loaded Core-Shell magnetic nanoparticles and cold atmospheric plasma inhibit non-small cell lung cancer growth. ACS Appl Mater Interfaces 10(50):43462–43471

    Google Scholar 

  • Zhang XF, Liu ZG, Shen W, Gurunathan S (2016) Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches. Int J Mol Sci 17(9):1534

    Google Scholar 

  • Zhang Q, Liu Q, Du M, Vermorken A, Cui Y, Zhang L, Guo L, Ma L, Chen M (2019a) Cetuximab and doxorubicin loaded dextran-coated Fe3O4 magnetic nanoparticles as novel targeted nanocarriers for non-small cell lung cancer. J Magn Magn Mater 481:122–128

    Google Scholar 

  • Zhang X, Tan Z, Jia K, Zhang W, Dang M (2019b) Rabdosia rubescens Linn: green synthesis of gold nanoparticles and their anti-cancer effects against human lung cancer cells A549. Artif Cells Nanomed Biotechnol 47(1):2171–2178

    Google Scholar 

  • Zheng Y, Zhang J, Zhang R, Luo Z, Wang C, Shi S (2019) Gold nanoparticles synthesised from Magnolia officinalis and anti-cancer activity in A549 lung cancer cells. Artif Cells Nanomed Biotechnol 47(1):3101–3109

    Google Scholar 

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Authors and Affiliations

  1. School of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan, India

    Harsh Kumar, K. Akash, Akriti Taneja & Shubhangi Singh

  2. School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, India

    Kanchan Bhardwaj

  3. Petroleum and Chemical Engineering Department, Faculty of Engineering, Universiti Teknologi Brunei, Bandar Seri Begawan, Brunei

    Sivakumar Manickam

  4. Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia

    Marian Valko

  5. Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic

    Kamil Kuča

  6. Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic

    Kamil Kuča

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  1. Harsh Kumar
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  2. K. Akash
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Kumar, H. et al. (2022). Applications of Metallic Nanoparticles in Lung Cancer Treatment. In: Interdisciplinary Cancer Research. Springer, Cham. https://doi.org/10.1007/16833_2022_51

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  • DOI: https://doi.org/10.1007/16833_2022_51

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