Abstract
Interest in the use of GC-IMS for the detection of volatiles has seen a rapid expansion over the last decade. The following chapter will focus on classical GC-IMS and its research applications in the potential for diagnosis, rapid testing and biomarker discovery, with an emphasis on breath testing. Breath analysis via GC-IMS has enormous potential in many clinical areas including screening for pulmonary diseases, infections and toxins. Due to the technology’s small footprint, robustness in various environments and ease of use, there have been many studies looking at its potential utility in the clinical field, including its use as a screening tool for SARS-CoV-2 infections. There remain limitations to the device usage and data processing which are discussed throughout the chapter. An introduction to its fundamentals, standardisation, breath collection methods and active areas of research and development will be covered.
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Notes
- 1.
Note: The extensive review on the studies of those effects and the IMS principles in general, its history and applications and future perspective can be found in “Ion Mobility Spectrometry” by G.A. Eiceman, Z. Karpas, and Herbert H. Hill, Jr. [5] an important and complete reference on GC-IMS technique.
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Acknowledgements
The authors would like to gratefully acknowledge: Prof. CL Paul Thomas from Loughborough University (UK) – coordinator of the Toxi-Triage project along with Prof. Michael Eddleston, Dr. Bill Nailon and Dr. Duncan McLaren (Edinburgh University UK and Western General Hospital Edinburgh) and Prof. Knut Erik Hovda (Norwegian National Unit for CBRNE Medicine and Oslo University Hospital Norway) – coordinators of the clinical studies for sharing data for this chapter. We also acknowledge the clinical research staff including Yvonee (Norway), Kareen Darnley (Edinburgh) and Dr. Chenery Lin from General Hospital in Jakarta (Indonesia) for their research/data contributions. We would also like to thank Dr. James Covington (Warwick University) for sharing his work on a data pipeline for GC-IMS processing.
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Ruszkiewicz, D.M., Meister, A., Myers, R. (2022). Ion Mobility Spectrometry in Clinical and Emergency Setting: Research and Potential Applications. In: Weigl, S. (eds) Breath Analysis . Bioanalytical Reviews, vol 4. Springer, Cham. https://doi.org/10.1007/11663_2022_20
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DOI: https://doi.org/10.1007/11663_2022_20
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