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Bile Acid Biology and its Therapeutic Implications

Proceedings of the Falk Symposium 141 (XVIII Internationale Bile Acid Meeting) held in Stockholm, Sweden, June 18 - 19, 2004

  • Conference proceedings
  • Mar 2005
  • Latest edition

Overview

Editors:
  1. G. Paumgartner

    1. Klinikum der Universität, München, Germany

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  2. D. Keppler

    1. Deutsches Krebsforschungszentrum, Heidelberg, Germany

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  3. U. Leuschner

    1. Internistisches Facharztzentrum, Frankfurt, Germany

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  4. A. Stiehl

    1. Klinikum der Universität, Heidelberg, Germany

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  • Interdisciplinary symposium bringing together basic science and clinical applications
  • Up-to-date research findings at the hightest scientific level

Part of the book series: Falk Symposium (FASS, volume 141)

  • 143 Accesses

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About this book

This book is the proceedings of the 18th International Bile Acid Meeting, held as the Falk Symposium 141 in Stockholm, Sweden, on June 18–19, 2004. The International Bile Acid Meetings have become some of the most important meetings in the bile acid field worldwide since Herbert Falk decided to sponsor these Symposia in biannual sequence in 1970. The 17 International Bile Acid Meetings in the past have been a great stimulus for new ideas and methods as well as the development of therapeutic applications of bile acids. They have always been a forum where basic scientists and clinicians interact. Many novel results of bile acid research were first presented at these meetings. The meeting in Stockholm again attracted a large number of basic and clinical scientists interested in bile acid and biliary research from all over the world.

Knowledge about the regulation of bile acid synthesis, bile acid transport and enterohepatic circulation in health and in disease has increased considerably during recent years. Accordingly, bile acid research is alive as ever. A new chapter of bile acid research was opened by the finding that bile acids are ligands of nuclear receptors which regulate synthesis, metabolism and transport of bile acids and steroids. A large part of the book is devoted to these topics.

The 18th International Bile Acid Meeting was again a truly interdisciplinary symposium at the highest scientific level. Its participants enjoyed hearing the latest reports on bile acid research in the city where so many seminal studies on bile acids were performed. It is hoped that the readers of this book will share the enjoyment.

Keywords

Table of contents (33 papers)

  1. Front Matter

    Pages i-xv
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  2. Presentation of the Adolf Windaus Prize 2004

    1. Presentation of the Adolf Windaus Prize 2004

      • G. Paumgartner
      Pages 1-2

  3. Adolf Windaus Prize Lecture 2004

    1. Adolf Windaus Prize Lecture 2004

      • K. D. R. Setchell
      Pages 3-16

  4. Synthesis and metabolism of bile acids

    1. Front Matter

      Pages 17-17
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    2. Multifunctional roles of bile acid biosynthetic enzymes and the isolation of a new vitamin D 25-hydroxylase

      • D. W. Russell, J. B. Cheng
      Pages 19-26

    3. Studies on biosynthetic pathways to bile acids in human liver cells

      • M. Axelson, B. Mörk, K. Garmark, J. Shoda, G. T. Everson, J. Sjövall
      Pages 27-36

    4. Role of CYP3A4 as a cholesterol and bile acid metabolizing enzyme

      • K. Bodin, U. Diczfalusy
      Pages 37-40

    5. New insights into bile acid amidation

      • M. C. Hunt, E. O’Shea, K. Solaas, B. Frode Kase, S. E. H. Alexson
      Pages 41-50

    6. Mechanisms of bile acid inhibition of bile acid synthesis

      • J. Y. L. Chiang, T. Li, B. Spalding-Yoder, S. Del Signore
      Pages 51-58

    7. The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion

      • J. Cui, J. -L. Lew, A. Zhao, L. Huang, S. D. Wright
      Pages 59-63

    8. Regulation of bile acid biosynthesis by cell signalling pathways

      • P. B. Hylemon, S. Gupta, R. Natarajan, P. Dent
      Pages 64-72

    9. Feedback regulation of human bile acid synthesis

      • E. C. S. Ellis, M. Axelson, A. Abrahamsson, G. Eggertsen, B. -G. Ericzon, I. Björkhem et al.
      Pages 73-79

    10. On the role of oxysterols in regulation of cholesterol homeostasis by nuclear receptors

      • S. Meaney, I. Björkhem
      Pages 80-87

  5. Transport of bile acids and lipids

    1. Front Matter

      Pages 89-89
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    2. Bile acid transport in Spgp (Bsep) knockout mice

      • P. Lam, R. Wang, V. Ling
      Pages 91-100

    3. Bile salt and glutathione coefflux mediated by multidrug resistance protein MRP4 (ABCC4), a basolateral transporter of the hepatocyte

      • M. Rius, A. T. Nies, A. F. Hofmann, D. Keppler
      Pages 101-106

    4. Role of farnesoid X receptor in regulating bile salt transport and synthesis

      • J. J. Eloranta, G. A. Kullak-Ublick
      Pages 107-117

    5. Gender-specific expression of liver organic anion transporters

      • D. Rost, K. Kopplow, S. Gehrke, A. Stiehl, D. Mayer
      Pages 118-121

    6. Molecular mechanisms of intestinal bile acid transport

      • P. A. Dawson, A. L. Craddock, J. H. Haywood, M. L. Hubbert, N. Ballatori
      Pages 122-129

    7. Adaptive regulation of bile salt transporters in cholestasis — the role of MRPs

      • W. S. Chen, A. Bohan, G. Denk, C. Soroka, L. Denson, J. L. Boyer
      Pages 130-131
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Editors and Affiliations

  • Klinikum der Universität, München, Germany

    G. Paumgartner

  • Deutsches Krebsforschungszentrum, Heidelberg, Germany

    D. Keppler

  • Internistisches Facharztzentrum, Frankfurt, Germany

    U. Leuschner

  • Klinikum der Universität, Heidelberg, Germany

    A. Stiehl

Bibliographic Information

  • Book Title: Bile Acid Biology and its Therapeutic Implications

  • Book Subtitle: Proceedings of the Falk Symposium 141 (XVIII Internationale Bile Acid Meeting) held in Stockholm, Sweden, June 18 - 19, 2004

  • Editors: G. Paumgartner, D. Keppler, U. Leuschner, A. Stiehl

  • Series Title: Falk Symposium

  • DOI: https://doi.org/10.1007/1-4020-2913-6

  • Publisher: Springer Dordrecht

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2005

  • Edition Number: 1

  • Number of Pages: XVI, 276

  • Topics: Hepatology, Gastroenterology

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