Abstract
Harmful viruses, including dengue virus, human immunodeficiency virus, and hepatitis B virus are known to be extremely sensitive to glucosidase inhibition. Phellinus linteus, an edible medicinal mushroom, was screened as an α-glucosidase inhibitor. The methanol extract of P. Linteus inhibited the trafficking process of Newcastle disease virus-hemagglutinin-neuramidase, a viral glycoprotein, in virus-infected baby hamster kidney cells. These results suggest that P. Linteus extract inhibits viral glycoprotein expression on cell surface through inhibition of trafficking process rather than glycoprotein synthesis.
References
Asano N (2003) Glycosidase inhibitors: update and perspectives on practical use. Glycobiology 13, 93–104.
Courageot MP, Frenkiel MP, Duarte Dos Santos C, Deubel V, and Despres P (2000) α-Glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum. J Virol 74, 564–572.
Dennis JW, Laferté S, Waghorne C, Breitman ML, and Kerbel RS (1987) Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 236, 582–585.
Einfeld D (1996) Maturation and assembly of retroviral glycoproteins. Curr Top Microbiol 214, 133–176.
Fischer PB, Collin M, Karlsson GB, James W, Butters TD, Davis SJ, Gordon S, Dwek RA, and Platt FM (1995) The á-glucosidase inhibitor N-buthyldeoxynojirimycin inhibits juman immunodeficiency virus entry at the level of post-CD4 binding. J Virol 69, 5791–5797.
Gruters RA, Neefjes JJ, Tersmette M, de Goede RE, Tulp A, Huisman HG, Miedemam F, and Ploegh HL (1987) Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 330, 74–77.
Johnson VA, Walker BD, Barlow MA, Paradis TJ, Chou TC, and Hirsch MS (1989) Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3′-azido-3′-deoxythymidine. Antimicrob Agents Chemother 33, 53–57.
Lee DS and Lee SH (2001) Genistein, a soy iso£avone, is a potent α-glucosidase inhibitor. FEBS Lett 501, 84–86.
Lu TL, Huang GJ, Lu TJ, Wu JB, Wu CH, Yang TC, Lizuka A, and Chen YF (2009) Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. Food Chem Toxicol 47, 2013–2021.
Muroi M, Takasu A, Yamasaki M, and Takatsuki A (1993) Folimycin (concanamycin A), an inhibitor of V-type H(+)-ATPase, blocks cell-surface expression of virus-envelope glycoproteins. Biochem Biophys Res Commun 193, 999–1005.
Nakamura M, Kono Y, and Takatsuki A (2003) Mepanipyrim, a novel inhibitor of pharmacologically induced Golgi dispersion. Biosci Biotechnol Biochem 67, 139–150.
Papandréou MJ, Barbouche R, Guieu R, Kieny MP, and Fenouillet E (2002) The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. Mol Pharmacol 61, 186–193.
Quinn TC (2008) HIV epidemiology and the effects of antiviral therapy on long-term consequences. AIDS 22 (Suppl 3), 7–12.
Zhu T, Kim SH, and Chen CY (2008) A medicinal mushroom: Phellinus linteus. Curr Med Chem 15, 1330–1335.
Author information
Authors and Affiliations
Corresponding author
Additional information
contributed equally.
Rights and permissions
About this article
Cite this article
Lee, D., Kim, SC., Kim, D. et al. Screening of Phellinus linteus, a medicinal mushroom, for anti-viral activity. J. Korean Soc. Appl. Biol. Chem. 54, 475–478 (2011). https://doi.org/10.3839/jksabc.2011.073
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.3839/jksabc.2011.073