Abstract
Inhibitory effects of lipid accumulation by citrus peel extract were evaluated. Citrus peel extract (CPE) (500 μg/mL) inhibited lipid and triglyceride accumulation in 3T3-L1 adipocytes by more than 64.5 and 58.7%, respectively and suppressed glycerol-3-phosphate dehydrogenase to the levels of preadipocytes. The expression of perilipin mRNA in 3T3-L1 adipocytes treated with CPE was significantly lower than that in untreated adipocytes (p<0.05), with no accompanying increase in lipolysis-related mRNA. Flavonoid compositions of CPE were hesperidin 13.79, narirutin 7, and naringin 262.5 μg/g, respectively. These findings suggest CPE may indirectly stimulate lipolysis by inhibiting protection of physical barrier on lipid droplet to hinder lipid accumulation in 3T3-L1 adipocytes.
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Jung, H.K., Jeong, Y.S., Park, CD. et al. Inhibitory effect of citrus peel extract on lipid accumulation of 3T3-L1 adipocytes. J. Korean Soc. Appl. Biol. Chem. 54, 169–176 (2011). https://doi.org/10.3839/jksabc.2011.028
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DOI: https://doi.org/10.3839/jksabc.2011.028