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Antibacterial Activity of Amphiphiles Based on Indolyl-3-Carboxylic Acids and L-Lysine with an Ethylenediamine Linker

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Moscow University Chemistry Bulletin Aims and scope

Abstract

Recently, due to the growth in bacterial infections resistant to antibiotics, there is an urgent need for develo** alternative antibacterial drugs. Alkyl-indolyl-L-lysines are a promising class of compounds; their amphiphilic structure is crucial in antimicrobial efficacy. A scheme is developed and five new derivatives of indolylbutyric and indolylacetic acids containing a polar amino acid residue with an ethylenediamine linker binding alkyl fragments with different lengths are synthesized. The antibacterial activity of the new amphiphiles against gram-positive and gram-negative bacterial strains is evaluated. The minimum binding energy of the synthesized compounds with human serum albumin (HSA) is determined by molecular docking. A lower affinity of the studied objects in comparison with control indolmycin is shown.

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ACKNOWLEDGMENTS

This study was performed using the equipment of the Shared Science and Training Center for Collective Use of MIREA–Russian Technological University.

Funding

This study was supported by the Ministry of Science and Higher Education of the Russian Federation (agreement no. 075-15-2021-689 dated September 1, 2021).

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Authors and Affiliations

  1. Lomonosov Institute of Fine Chemical Technology, MIREA—Russian Technological University, 119454, Moscow, Russia

    V. O. Ovsyannikov, A. Yu. Mikhailova, U. A. Budanova & Yu. L. Sebyakin

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  1. V. O. Ovsyannikov
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  2. A. Yu. Mikhailova
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  3. U. A. Budanova
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  4. Yu. L. Sebyakin
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All the authors contributed equally to the preparation of this publication.

Corresponding author

Correspondence to U. A. Budanova.

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The authors of this work declare that they have no conflicts of interest.

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Translated by E. Boltukhina

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Ovsyannikov, V.O., Mikhailova, A.Y., Budanova, U.A. et al. Antibacterial Activity of Amphiphiles Based on Indolyl-3-Carboxylic Acids and L-Lysine with an Ethylenediamine Linker. Moscow Univ. Chem. Bull. 79, 217–224 (2024). https://doi.org/10.3103/S0027131424700202

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  • DOI: https://doi.org/10.3103/S0027131424700202

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