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Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives

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Moscow University Chemistry Bulletin Aims and scope

Abstract

We study the effect of the nature of the substituent in the β-cyclodextrin derivative on the physicochemical properties of the antibacterial drug ciprofloxacin (CF). CF can form guest–host inclusion complexes with β-cyclodextrin derivatives, characterized by dissociation constants (Kdis) in the range of 10–3 to 10–4 M. A ligand with a small polar uncharged substituent (2-hydroxypropyl) form of the most stable complex, which also helps to increase the solubility of CF by 20 and 64% in buffer systems having a pH of 4.0 and 7.4, respectively. The inclusion of CF in a complex with Kdis = 10–3 M or lower contributes to a slower release of the drug. The physicochemical properties of the obtained complexes allow develo** a highly effective formulation of the drug.

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ACKNOWLEDGMENTS

This work was supported by the UMNIK program.

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, 119991, Moscow, Russia

    A. A. Skuredina, T. Yu. Kopnova, I. M. Le-Deygen & E. V. Kudryashova

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  1. A. A. Skuredina
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  2. T. Yu. Kopnova
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  3. I. M. Le-Deygen
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  4. E. V. Kudryashova
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Correspondence to A. A. Skuredina.

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Translated by O. Zhukova

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Skuredina, A.A., Kopnova, T.Y., Le-Deygen, I.M. et al. Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives. Moscow Univ. Chem. Bull. 75, 218–224 (2020). https://doi.org/10.3103/S0027131420040069

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