Abstract
Over the past decade, there has been increasing attention on the interaction between microbiota and bile acid metabolism. Bile acids are not only involved in the metabolism of nutrients, but are also important in signal transduction for the regulation of host physiological activities. Microbial-regulated bile acid metabolism has been proven to affect many diseases, but there have not been many studies of disease regulation by microbial receptor signaling pathways. This review considers findings of recent research on the core roles of farnesoid X receptor (FXR), G protein-coupled bile acid receptor (TGR5), and vitamin D receptor (VDR) signaling pathways in microbial–host interactions in health and disease. Studying the relationship between these pathways can help us understand the pathogenesis of human diseases, and lead to new solutions for their treatments.
概要
**十年来, 微生物与胆汁酸代谢的相互作用越来越受到关注。 胆汁酸不仅参与营养物质的代谢, 而且在调节宿主生理活动的信号转导中也起着重要作用。 已有研究表明, 微生物调控的胆汁酸代谢对许多疾病都有显著的影响, 但对微生物受体信号通路调控疾病的相关研究并不多。 本文综述了**年来有关法尼醇受体 (FXR)、 G 蛋白偶联胆汁酸受体 (TGR5) 和维生素 D 受体 (VDR) 信号通路在健康和疾病的微生物-宿主相互作用中的核心作用。 研究这些信号通路之间的关系, 有助于我们了解人类疾病的发病机制, 为人类疾病的治疗提供新的解决方案。
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Er-teng JIA and Qin-yu GE designed the research. Er-teng JIA wrote the manuscript. Zhi-yu LIU, Min PAN, Jia-feng LU, and Qin-yu GE provided guidance on the writ¬ing of this review. All authors read and approved the final manuscript.
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Er-teng JIA, Zhi-yu LIU, Min PAN, Jia-feng LU, and Qin-yu GE declare that they have no conflict of interest.
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Project supported by the National Key Research and Development Program of China (No. 2016YFA0501602) and the National Natural Science Foundation of China (Nos. 61801108 and 81801478)
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Jia, Et., Liu, Zy., Pan, M. et al. Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases. J. Zhejiang Univ. Sci. B 20, 781–792 (2019). https://doi.org/10.1631/jzus.B1900073
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DOI: https://doi.org/10.1631/jzus.B1900073