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Fluorescence modulation of nanodiamond NV− centers for neurochemical detection

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Abstract

Nanodiamond (ND) with nitrogen vacancy (NV−) color centers has emerged as an important material for quantum sensing and imaging. Fluorescent, carboxylated ND (140 nm) is investigated for the detection of dopamine (DA), caffeine (CA), and ascorbic acid (AA). Over a 200 nM range, DA and CA quenched the ND fluorescence by 7.1 and 9.8%, respectively. For AA, fluorescence was quenched (2.9%) at nM concentrations and enhanced at μM concentrations. The quenching fit well to Langmuir adsorption isotherms. For DA-CA mixtures, the CA at nM concentrations did not affect DA quenching but interfered when at μM concentrations. The DA at nM or μM concentrations lessened CA quenching. For DA-AA mixtures with DA at mM concentrations, AA quenched fluorescence throughout the nM and μM range, with increased quenching in the nM range. These studies support ND fluorescence modulation as a possible sensor modality for bioanalyte detection.

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Data availability

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgments

M. Rashwan acknowledges the guidance of Prof. Hassan Azab in fluorescence techniques. Prof. Christopher Wirth and Aiden Rashidi helped with zeta potential measurements. This work was supported in part by a grant from the National Institutes of Health: EB021911 (to H.B.) The funding support of the Egyptian and Cultural Bureau is also gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemical & Biomolecular Engineering, Case Western Reserve University, Cleveland, OH, USA

    Mai S. Rashwan, Harihara Baskaran & Heidi B. Martin

  2. Department of Chemistry, Suez Canal University, Ismailia, Egypt

    Mai S. Rashwan & Zeinab M. Anwar

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  1. Mai S. Rashwan
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  2. Zeinab M. Anwar
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  3. Harihara Baskaran
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  4. Heidi B. Martin
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Correspondence to Heidi B. Martin.

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Rashwan, M.S., Anwar, Z.M., Baskaran, H. et al. Fluorescence modulation of nanodiamond NV− centers for neurochemical detection. MRS Advances 7, 766–771 (2022). https://doi.org/10.1557/s43580-022-00322-2

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