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Investigation of Interaction of Fluoroquinolones with Aluminum, Iron and Magnesium ions Using Capillary Zone Eletrophoresis

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Abstract

The present study describes the application of capillary zone electrophoresis (CZE) to investigate interactions between ciprofloxacin, enrofloxacin, lomefloxacin, levofloxacin, ofloxacin, norfloxacin and sparfloxacin—antimicrobial drugs called fluoroqinolones, and polyvalent metal ions (Mg2+, Fe3+ and Al3+), commonly used in daily medicine practice as components of multi-mineral and antacida drugs. It was observed that polyvalent metal ions exhibit strong interactions with these drugs. The strength of these interactions depends on the metal ion, the molecular structure of the fluoroquinolone, and the pH which is very important for the investigations of complex formations. Two different pH values, 3.25 and 8.02, were utilized in this study. Addition of fluoroquinolone to background electrolyte and injection of samples consisting of different concentrations of cations allowed to observe changes in peak area depending on the concentration of the metal ion. A mathematical model for quantitative evaluation of the complex formation constant K was used. Our investigation shows new possibilities of quantitative characterization of the interactions between fluoroquinolones and metal ions using CZE. Such investigations were not described so far in the literature.

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References

  1. Turel I, Coord (2000) Chem Rev 232:27–47

  2. Lomaestro BM, Bailie GR (1995) Drug Saf 12:314–333

    Article  CAS  Google Scholar 

  3. Corboba-Diaz M, Cordoba-Borrego M, Cordoba-Diaz D (1998) J Pharm Biomed Anal 18:565–571

    Article  Google Scholar 

  4. Rodriguez Cruz MS, Gonzalez Alonso I, Sanchez-Navarro A, Sayaler Marinero ML (1999) Pharm Acta Helv 73:237–245

    Article  CAS  Google Scholar 

  5. Sissi C, Andreolli M, Cecchetti V, Fravolini A, Gatto B, Palumbo M (1998) Bioorg Med Chem 6:1551–1561

    Article  Google Scholar 

  6. Lecomte S, Moreau JM, Chenon MT (1998) Int J Pharm 164:57–56

    Article  CAS  Google Scholar 

  7. Bush MHA, Carles LB, Boelens HFM, Kraak JC, Poppe H (1997) J Chromatogr A 777:311–328

    Article  Google Scholar 

  8. Busch MHA, Kraak JC, Poppe H (1997) J Chromatogr A 777:329–353

    Article  CAS  Google Scholar 

  9. Al-Ahrabi M, Mrestani Y, Richter H, Neubert RHH (2002) J Pharm Biomed Anal 29:555–560

    Article  Google Scholar 

  10. Mrestani Y, Neubert RHH (2000) J Chromatogr A 871:439–448

    Article  CAS  Google Scholar 

  11. Stricker H (1997) Physikalische Pharmazie. Wissenschafliche Verlagsgesellschaft GmbH Stuttgart, pp 168–171

  12. He X, Ding Y, Li D, Lin B (2004) Electrophoresis 25:697–711

    Article  CAS  Google Scholar 

  13. Kawai Y, Matsubayashi K, Hakusui H (1996) Chem Pharm Bull 44:1425–1430

    CAS  Google Scholar 

  14. Djurdjevic PT, Jelikic-Stankov M (1999) J Pharm Biomed Anal 19:501–510

    Article  CAS  Google Scholar 

  15. Azcurra AI, Yudi LM, Baruzzi AM (2003) J Electroanal Chem 560:35–42

    Article  CAS  Google Scholar 

  16. Kapetanovic V, Milovanovic Lj, Erceg M (1996) Talanta 43:2123–2130

    Article  CAS  Google Scholar 

  17. Wallis SC, Charles BC, Gahan LR, Fillipich LJ, Bredhauer MG, Duckworth PA (1996) J Pharm Sci 85:803–809

    Article  CAS  Google Scholar 

  18. Turel I, Bukovec N, Farkas E (1996) Polyhedron 15:269–275

    Article  CAS  Google Scholar 

  19. Stricker H (1997) Physikalische Pharmazie, Wissenschaftliche Verlagsgesellschaft GmbH, Stuttgart, Germany, pp 168–171

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Acknowledgments

Bartosz Urbaniak would like to thank the Martin-Luther-University for the grant.

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Authors and Affiliations

  1. Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka Str. 6, 60-780, Poznan, Poland

    B. Urbaniak & Z. J. Kokot

  2. Institute of Pharmaceutics and Biopharmaceutics, Martin-Luther-University, Wolfgang-Langenbeck-Str. 4, 06120, Halle/S., Germany

    Y. Mrestani & R. H. H. Neubert

Authors
  1. B. Urbaniak
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  2. Y. Mrestani
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  3. Z. J. Kokot
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  4. R. H. H. Neubert
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Correspondence to Y. Mrestani.

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Urbaniak, B., Mrestani, Y., Kokot, Z.J. et al. Investigation of Interaction of Fluoroquinolones with Aluminum, Iron and Magnesium ions Using Capillary Zone Eletrophoresis. Chroma 65, 489–492 (2007). https://doi.org/10.1365/s10337-007-0180-3

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  • DOI: https://doi.org/10.1365/s10337-007-0180-3

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