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Prognostic Factors of 30-Day Mortality After Palliative Procedures in Patients with Malignant Pleural Effusion

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The aim of this study was to identify predictors of 30-day mortality in patients with malignant pleural effusion (MPE) who need pleural palliative procedures.

Methods

Data was prospectively collected from our database, between January 2013 and July 2014 on 86 patients with MPE and complete follow-up 30 days after the procedure. The sample was divided into two groups. The first group (G1) included patients who had died up to 30 days after the palliative procedure, and the second group (G2) included patients who survived for more than 30 days after the palliative procedure. The identification of prognostic factors occurred through univariate analysis using Fisher exact test for analysis of categorical variables and the t test for quantitative variables. Subsequently, all variables were used in the multivariate logistic regression analysis. The cutoff values for any significant continuous variables were determined by receiver operating characteristics analysis.

Results

There were 24 patients in G1 and 62 patients in G2. Univariate analysis of factors affecting postprocedural survival disclosed nine factors that were associated with significantly reduced postoperative survival. At the multivariate analysis, high levels of white blood cells, (p = .013), low levels of red blood cells (p < .0001) and protein in pleural fluid (p = .001), and primary lung and gastrointestinal sites (p = .0076) were identified as independent predictors of mortality.

Conclusions

We identified four factors that are easily recognized in daily practice and can help select patients with low life expectancy. Therefore, invasive procedures and hospitalizations for this subgroup of patients can be prevented.

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Disclosure

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Hospital São José, São Paulo, SP, Brazil

    Fernando Conrado Abrao MD & Riad Naim Younes PhD

  2. Department of Thoracic Surgery, Hospital Santa Marcelina, São Paulo, Brazil

    Igor Renato Louro Bruno de Abreu MD, Mariana Fogarolli MD, Giovanna Caxeiro MD, Camila Borges Saes Bezerra MD, Fernanda Prado de Cerqueira Cesar MD & Poline Spitti Rocha MD

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  1. Fernando Conrado Abrao MD
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  2. Igor Renato Louro Bruno de Abreu MD
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  3. Mariana Fogarolli MD
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  4. Giovanna Caxeiro MD
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  5. Camila Borges Saes Bezerra MD
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  8. Riad Naim Younes PhD
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Correspondence to Fernando Conrado Abrao MD.

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Abrao, F.C., de Abreu, I.R.L.B., Fogarolli, M. et al. Prognostic Factors of 30-Day Mortality After Palliative Procedures in Patients with Malignant Pleural Effusion. Ann Surg Oncol 22, 4083–4088 (2015). https://doi.org/10.1245/s10434-015-4491-6

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  • DOI: https://doi.org/10.1245/s10434-015-4491-6

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