Abstract
Cyclodextrin metal-organic frameworks (CD-MOFs) exhibit a high structural diversity, which contributes to their functional properties. In this study, we have successfully synthesized a novel type of β-cyclodextrin metal-organic framework (β-CD-POF(I)) that exhibits excellent drug adsorption capacity and enhances stability. Single-crystal X-ray diffraction analysis revealed that β-CD-POF(I) possessed the dicyclodextrin channel moieties and long-parallel tubular cavities. Compared with the reported β-CD-MOFs, the β-CD-POF(I) has a more promising drug encapsulation capability. Here, the stability of vitamin A palmitate (VAP) was effectively improved by the solvent-free method. Molecular modeling and other characterization techniques like synchrotron radiation Fourier transform infrared spectroscopy (SR-FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), and nitrogen adsorption isotherm were applied to confirm that the VAP was successfully encapsulated into the channel formed by the dicyclodextrin pairs. Furthermore, the mechanism of stability enhancement for VAP was determined to be due to the constraint and separation effects of β-CD pairs on VAP. Therefore, β-CD-POF(I) is capable of trap** and stabilizing certain unstable drug molecules, offering benefits and application possibilities.
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Acknowledgements
The authors are thankful for the financial support from the National Natural Science Foundation of China (82273863). Thanks go to the staff from BL01B beamline of the National Facility for Protein Science in Shanghai (NFPS) at Shanghai Synchrotron Radiation Facility for assistance during data collection.
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Ying Zhang carried out most experiments under the guidance of Jiwen Zhang, Li Wu, Tao Guo, and Weidong Chen. Zaiyong Zhang and Jiacai Chen helped to accomplish the cultivation and optimization of the single crystal. Caifen Wang, Huajie Zhu, and **angyu Zhao helped with the stability experiment and quantification. Wuzhen Ma and Manli Wang assisted with the review. Abid Naeem helped to improve the English style and rectify any grammatical mistakes. All authors discussed the results and commented on the manuscript.
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Zhang, Y., Chen, J., Zhang, Z. et al. Solvent-Free Loading of Vitamin A Palmitate into β-Cyclodextrin Metal-Organic Frameworks for Stability Enhancement. AAPS PharmSciTech 24, 136 (2023). https://doi.org/10.1208/s12249-023-02596-7
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DOI: https://doi.org/10.1208/s12249-023-02596-7