Abstract
INTRODUCTION Kawasaki disease is replacing rheumatic fever as the most common cause of acquired heart disease. The clinical appraisal of Kawasaki disease in Indian scenario is being recently recognized. We are reporting eight typical cases of Kawasaki disease.
AIMS to study the clinical spectrum of Kawasaki disease to study the utility of investigatory tools. To study the efficacy of Intravenous Immunoglobulins vs methylprednisolone.
MATERIALS AND METHODS: Children with fever and rash were screened for Kawasaki diseases per the guidelines of International Kawasaki disease criteria. All children of suspected Kawasaki disease were subjected to 2D-COLOUR DOPPLER and ECG for cardiac involvement and those with cardiac involvement were followed for coronary aneurysms irrespective of nature of treatment. The children were divided into two groups, first group were treated with 2gm/kg Immunoglobulin as a single dose infusion over a period of 12 hrs and aspirin therapy whereas the second group received Methyl prednisolone 30mg/kg /day for 5 days and aspirin. Aspirin is used initially in the dose of 30–50mg/kg/day in 4 divided doses for 2 weeks followed by 2–5mg/kg/day as a single dose until the platelet count returned to normal. All the data is analysed and tabulated.
RESULTS A total of 8 cases were reported in 2 year period, 7 were females and 1 was male. All the cases were younger than 6 years of age. Cardiac involvement was seen in 50% of cases. Response to intravenous immunoglobulins is dramatic and complete within 2 days, whereas response to methylprednisolone is incomplete and prolonged. Coronary aneurysm was seen in one child who was treated with methylprednisolone. Time taken for platelet count to come to normal is unaffected by nature of therapy.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kalepu, R., Sudhakar, G., Rao, S. et al. 189 Kawasaki Disease- A Prospective Clinical Appraisal. Pediatr Res 58, 387 (2005). https://doi.org/10.1203/00006450-200508000-00218
Issue Date:
DOI: https://doi.org/10.1203/00006450-200508000-00218
- Springer Nature America, Inc.