Abstract
Тhis work suggests ways to improve the bioavailability of low-solubility drugs by precipitation from solutions in universal solvents on nanostructured surfaces including nanoparticles (NPs) such as SiO2 and Fe3O4. The same effect is found on metal-polymer composites containing Co, Ni, and Fe obtained from unsaturated dicarboxylates. In both cases, this is achieved by increasing the total desorption surface. The examples of resveratrol and of the preparation of the sum of furocoumarins Ammifurin show an increase of the relative desorption ratio of drugs by two orders of magnitude from the surface of nanostructured CaCO3 particles into aqueous solutions. The results of MTT tests show the comparable effects of Ammifurin and of the used metal-polymer nanocomposites on HeLa cervical cancer cells and human HepG2 liver carcinoma, thereby making their combined use potentially possible. Thus, we propose a way to improve the bioavailability of a wide class of drugs, potentially applicable for all cases when the toxicity of the carrier NPs does not exceed the independent toxicity of the target substance. The possibility of the mutual enhancement of toxicity requires a separate study and is not considered here.
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ACKNOWLEDGMENTS
We express our gratitude to K.V. Palamarchuk for the synthesis of Fe3O4 NPs and the provision of SiO2 NPs for experiments, R.A. Kamyshinsky (Resource Center “Nanoprobe,” National Research Center “Kurchatov Institute”) for obtaining SEM images, S.N. Malakhov (Resource Center “Optics,” National Research Center “Kurchatov Institute”) for assistance in spectrophotometry. The results were obtained using the “Optics,” “Polymer,” and “Nanoprobe” Resource Centers of the National Research Center “Kurchatov Institute.”
Funding
This work was funded in part by the National Research Center “Kurchatov Institute,” Order 116 of January 30, 2018. No additional grants were received to conduct or direct this specific study.
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Smirnova, O.D., Musatova, V.Y., Kalashnikova, I.V. et al. Improvement of the Bioavailability of Low-Solubility Drugs by Reprecipitation on Nanostructured Surfaces. Nanotechnol Russia 18 (Suppl 2), S398–S406 (2023). https://doi.org/10.1134/S2635167623601262
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DOI: https://doi.org/10.1134/S2635167623601262