Abstract
This work is aimed at develo** new materials with adjustable composition, microstructure, and properties for replacing osteochondral defects. Features of the interaction of components in the biopolymers–calcium phosphates systems were revealed, processes of the formation of framework structures of the composite material were determined, and their mechanical, chemical, and structural characteristics were examined. Experiments were carried out to simulate the behavior of matrices and changes in their properties during exposure to model body fluids.
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS2075113321010408/MediaObjects/13188_2021_1528_Fig1_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS2075113321010408/MediaObjects/13188_2021_1528_Fig2_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS2075113321010408/MediaObjects/13188_2021_1528_Fig3_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS2075113321010408/MediaObjects/13188_2021_1528_Fig4_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS2075113321010408/MediaObjects/13188_2021_1528_Fig5_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS2075113321010408/MediaObjects/13188_2021_1528_Fig6_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS2075113321010408/MediaObjects/13188_2021_1528_Fig7_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1134%2FS2075113321010408/MediaObjects/13188_2021_1528_Fig8_HTML.gif)
Similar content being viewed by others
REFERENCES
Rodriguez Garcia, M., Naves Diaz, M., and Cannata Andia, J.B., Bone metabolism, vascular calcifications and mortality: associations beyond mere coincidence, J. Nephrol., 2005, vol. 18, no. 4, pp. 458–63.
Mogosanu, G.D. and Grumezescu, A.M., Natural and synthetic polymers for wounds and burns dressing, Pharm. Int. J., 2014, vol. 463, pp. 127–136.
Siddhesh, N.P. and Kevin, J.E., Alginate derivatization: a review of chemistry, properties and applications, Biomaterials, 2012, vol. 33, no. 11, pp. 3279–3305.
Sime, W.J., Alginates, in Food Gels, New York: Springer-Verlag, 1990.
Lee, K.Y. and Mooney, D.J., Alginate: properties and biomedical applications, Prog. Polym. Sci., 2012, vol. 37, no. 1, pp. 106–126.
Shchipunov, Yu.A., Koneva, E.L., and Postnova, I.V., Homogeneous alginate gels: phase behavior and rheological properties, Polym. Sci., Ser. A, 2002, vol. 44, no. 7, pp. 758–766.
Barinov, S.M. and Komplev, V.S., Biokeramika na osnove fosfatov kal’tsiya (Bioceramics Based on Calcium Phosphate), Moscow: Nauka, 2005.
Komlev, V.S., Barinov, S.M., and Koplik, E.V., A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release, Biomaterials, 2002, vol. 23, pp. 3449–3454.
Musskaya, O.N., Krut’ko, V.K., Kulak, A.I., Filatov, S.A., Batyrev, E.V., and Safronova, T.V., Calcium phosphate compositions with polyvinyl alcohol for 3D-printing, Inorg. Mater.: Appl. Res., 2020, vol. 11, no. 1, pp. 192–197.
Zuev, D.M., Klimashina, E.S., Evdokimov, P.V., Filippov, Ya.Yu., and Putlyaev, V.I., Mechanical characteristics of composites based on β-Ca3(PO4)2/poly(D,L-lactide) and β-Ca3(PO4)2/poly(ε-caprolactone), Inorg. Mater.: Appl. Res., 2019, vol. 10, no. 1, pp. 109–113.
Funding
This work was carried out with the financial support of the Russian Foundation for Basic Research, grant 18-33-00955 mol_a. The viscosity of the hydrogels was investigated within the framework of the state assignment no. 007-00129-18-00.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The authors declare that they have no conflict of interest.
Additional information
Translated by K. Lazarev
Rights and permissions
About this article
Cite this article
Teterina, A.Y., Fetisova, V.E., Fedotov, A.Y. et al. Biocompatible Biodegradable Composite Materials in the Biopolymer–Calcium Phosphate System for Replacing Osteochondral Defects. Inorg. Mater. Appl. Res. 12, 242–249 (2021). https://doi.org/10.1134/S2075113321010408
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S2075113321010408