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Biocompatible Biodegradable Composite Materials in the Biopolymer–Calcium Phosphate System for Replacing Osteochondral Defects

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Inorganic Materials: Applied Research Aims and scope

Abstract

This work is aimed at develo** new materials with adjustable composition, microstructure, and properties for replacing osteochondral defects. Features of the interaction of components in the biopolymers–calcium phosphates systems were revealed, processes of the formation of framework structures of the composite material were determined, and their mechanical, chemical, and structural characteristics were examined. Experiments were carried out to simulate the behavior of matrices and changes in their properties during exposure to model body fluids.

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REFERENCES

  1. Rodriguez Garcia, M., Naves Diaz, M., and Cannata Andia, J.B., Bone metabolism, vascular calcifications and mortality: associations beyond mere coincidence, J. Nephrol., 2005, vol. 18, no. 4, pp. 458–63.

    CAS  PubMed  Google Scholar 

  2. Mogosanu, G.D. and Grumezescu, A.M., Natural and synthetic polymers for wounds and burns dressing, Pharm. Int. J., 2014, vol. 463, pp. 127–136.

    Article  CAS  Google Scholar 

  3. Siddhesh, N.P. and Kevin, J.E., Alginate derivatization: a review of chemistry, properties and applications, Biomaterials, 2012, vol. 33, no. 11, pp. 3279–3305.

    Article  Google Scholar 

  4. Sime, W.J., Alginates, in Food Gels, New York: Springer-Verlag, 1990.

    Google Scholar 

  5. Lee, K.Y. and Mooney, D.J., Alginate: properties and biomedical applications, Prog. Polym. Sci., 2012, vol. 37, no. 1, pp. 106–126.

    Article  CAS  Google Scholar 

  6. Shchipunov, Yu.A., Koneva, E.L., and Postnova, I.V., Homogeneous alginate gels: phase behavior and rheological properties, Polym. Sci., Ser. A, 2002, vol. 44, no. 7, pp. 758–766.

    Google Scholar 

  7. Barinov, S.M. and Komplev, V.S., Biokeramika na osnove fosfatov kal’tsiya (Bioceramics Based on Calcium Phosphate), Moscow: Nauka, 2005.

  8. Komlev, V.S., Barinov, S.M., and Koplik, E.V., A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release, Biomaterials, 2002, vol. 23, pp. 3449–3454.

    Article  CAS  Google Scholar 

  9. Musskaya, O.N., Krut’ko, V.K., Kulak, A.I., Filatov, S.A., Batyrev, E.V., and Safronova, T.V., Calcium phosphate compositions with polyvinyl alcohol for 3D-printing, Inorg. Mater.: Appl. Res., 2020, vol. 11, no. 1, pp. 192–197.

    Article  Google Scholar 

  10. Zuev, D.M., Klimashina, E.S., Evdokimov, P.V., Filippov, Ya.Yu., and Putlyaev, V.I., Mechanical characteristics of composites based on β-Ca3(PO4)2/poly(D,L-lactide) and β-Ca3(PO4)2/poly(ε-caprolactone), Inorg. Mater.: Appl. Res., 2019, vol. 10, no. 1, pp. 109–113.

    Article  Google Scholar 

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Funding

This work was carried out with the financial support of the Russian Foundation for Basic Research, grant 18-33-00955 mol_a. The viscosity of the hydrogels was investigated within the framework of the state assignment no. 007-00129-18-00.

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Correspondence to A. Yu. Teterina.

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The authors declare that they have no conflict of interest.

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Translated by K. Lazarev

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Teterina, A.Y., Fetisova, V.E., Fedotov, A.Y. et al. Biocompatible Biodegradable Composite Materials in the Biopolymer–Calcium Phosphate System for Replacing Osteochondral Defects. Inorg. Mater. Appl. Res. 12, 242–249 (2021). https://doi.org/10.1134/S2075113321010408

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  • DOI: https://doi.org/10.1134/S2075113321010408

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