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The Role of TNF-α, TNFRSF1A, and CD40 Gene Polymorphisms in Multiple Sclerosis in the Tomsk Region

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Abstract—We studied the role of the rs1800629 polymorphism of the TNF-α gene; the rs4149584 polymorphism of the TNFRSF1A gene; and the rs6074022, rs1883832, rs1535045, and rs11086996 polymorphisms of the CD40 gene in the onset, clinical course, and response to treatment in multiple sclerosis (MS) in a group of 152 patients living in Tomsk region. A total of 707 volunteers without autoimmune diseases and pathology of the nervous system were included in the control group. The C allele of the rs6074022 polymorphism of CD40 gene was associated with the risk of MS and contributed to the high rate of disease progression. The T allele of the rs6074022 polymorphism of the CD40 gene showed a significant association with the average rate of disease progression, and the GA genotype of the rs1800629 polymorphism of the TNF-α gene was associated with a higher frequency of MS exacerbation. Other polymorphisms did not demonstrate an association with both the risk of disease, the clinical features and response to treatment.

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Funding

The laboratory part of the study was supported by the Russian federal target program “Scientific and scientific-pedagogical personnel of innovative Russia” (2012-1.5-12-000-1002). State contract No. 8490.

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Authors and Affiliations

  1. Department of Neurology and Neurosurgery, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    M. A. Titova, V. M. Alifirova & N. F. Musina

  2. Neurology Clinic, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    T. N. Nikolaeva

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  1. M. A. Titova
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  2. V. M. Alifirova
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  3. N. F. Musina
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  4. T. N. Nikolaeva
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Correspondence to M. A. Titova.

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Conflict of interests. The authors declare that they have no conflicts of interest.

Ethical approval. All procedures performed in a human study comply with the ethical standards of the National Committee for Research Ethics, the Declaration of Helsinki of 1964 with its subsequent amendments, and the Rules of Clinical Practice in the Russian Federation, approved by the Order of the Ministry of Health of the Russian Federation dated June 19, 2003 No. 266. The study was approved by the Ethics Committee of the Siberian State Medical University of the Ministry of Health of Russia on February 24, 2014, conclusion No. 3604.

Informed consent. Voluntary informed consent was obtained from each study participant.

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Corresponding author; address: Moskovsky Trakt 2, Tomsk, 634050 Russia; e-mail: titovam82@list.ru.

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Titova, M.A., Alifirova, V.M., Musina, N.F. et al. The Role of TNF-α, TNFRSF1A, and CD40 Gene Polymorphisms in Multiple Sclerosis in the Tomsk Region. Neurochem. J. 17, 412–417 (2023). https://doi.org/10.1134/S1819712423020150

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  • DOI: https://doi.org/10.1134/S1819712423020150

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