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Intermolecular Interactions between Iodine and Low-Methoxylated Apple Pectin Modified with Pharmacophores

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Abstract

The interaction of iodine with low-methoxylated apple pectin (esterification degree 10%) modified with pharmacophores (salicylic, 5-aminosalicylic, and anthranilic acids) in aqueous solution has been investigated by spectral methods. Composition and stability constants of the iodine-containing complexes have been determined, and standard thermodynamic parameters of the complex formation have been calculated. Formation of the molecular 1 : 1 complexes in the considered systems has been governed by the enthalpy term (∆Н° < 0, ∆S° < 0). It has been found that hydroxyl as well as amino groups of the modified polysaccharide matrix can act as the main active sites involved in the interaction with iodine. The influence of the degree of methoxylation of the polysaccharide matrix and the structure of the modifying pharmacophore on the content of iodine, duration of the iodine release from the sample, and the antimicrobial activity has been demonstrated.

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ACKNOWLEDGMENTS

This study was performed in the scope of the Program of Fundamental Research at State Institutes for 2022/2024 (the State Task “Development of Fundamental Principles of Control of the Polymers Structure and Kinetics of the Processes in Catalytic Polymerization, Targeted Modification of Synthetic and Biogenic Polymers, and Preparation of Polymer Systems for Biomedical Applications” no. 1021062311391-0-1.4.4) using the equipment of the Center for Collective Usage “Chemistry” of Ufa Institute of Chemistry, RAS and Regional Center for Collective Usage “Agidel’”, Ufa Federal Research Center, Russian Academy of Sciences.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 450054, Ufa, Russia

    R. Kh. Mudarisova & S. V. Kolesov

  2. Bashkir State University, 450014, Ufa, Russia

    A. F. Sagitova & O. S. Kukovinets

Authors
  1. R. Kh. Mudarisova
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  2. A. F. Sagitova
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  3. O. S. Kukovinets
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  4. S. V. Kolesov
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Correspondence to R. Kh. Mudarisova.

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Translated by E. Karpushkin

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Mudarisova, R.K., Sagitova, A.F., Kukovinets, O.S. et al. Intermolecular Interactions between Iodine and Low-Methoxylated Apple Pectin Modified with Pharmacophores. Polym. Sci. Ser. B 65, 26–34 (2023). https://doi.org/10.1134/S1560090423700732

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  • DOI: https://doi.org/10.1134/S1560090423700732

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