Abstract
This work is a review of scientific research on the development of nuclear physics methods and technologies for medicine.1 The most relevant results, many of which are already used in the practical treatment of patients, are considered. New methods for improving the quality (quality assurance) of radiation therapy during irradiation with bremsstrahlung photon and proton beams are proposed. Methods for improving the accuracy of magnetic resonance imaging (MRI) tomography of pathological foci in the planning of radiation therapy are described. In nuclear medicine, methods for producing radionuclides on electron accelerators for immune positron emission tomography (PET) diagnostics and targeted radiotherapy are proposed. New results in biomedical applications of radiation technologies (for food processing and sterilization of bioimplants) are presented.
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Notes
It has been carried out over the past 10 years by staff members and graduate students of the Department of Accelerator Physics and Radiation Medicine, Faculty of Physics, Moscow State University, together with staff members of medical oncological and scientific centers.
The work was carried out in collaboration with Burnazyan Federal Medical Biophysical Center at the Federal Medical-Biological Agency of the Russian Federation, the Pletnev City Clinical Hospital, and the Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation.
Rogachev National Medical Research Center of Paediatric Hematology, Oncology, and Immunology.
International Society of Paediatric Oncology.
Rescanning is the repeated scanning of an irradiated volume.
The work was carried out in collaboration with the All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia) and the Ammosov Northeastern Federal University (Yakutsk, Russia).
REFERENCES
R. M. Howell, S. F. Kry, E. Burgett, N. E. Hertel, et al. “Secondary neutron spectra from modern Varian, Siemens, and Elekta linacs with multileaf collimators,” Med. Phys. 36,4027–4038 (2009).
S. A. Martínez-Ovalle, R. Barquero, J. M. Gómez-Ros, and A. M. Lallena, “Neutron dose equivalent and neutron spectra in tissue for clinical linacs operating at 15, 18 and 20 MV,” Radiat. Prot. Dosim. 147, 498–511 (2011).
F. Sanchez-Doblado, C. Domingo, F. Gomez, et al., “Estimation of neutron-equivalent dose in organs of patients undergoing radiotherapy by the use of a novel online digital detector,” Phys. Med. Biol. 57, 6167–6191 (2012).
E. N. Lykova, M. V. Zheltonozhskaya, F. Yu. Smirnov, et al. “Investigation of the bremsstrahlung photon and neutron flux during the operation of a medical electron accelerator,” Med. Radiol. Rad. Bezopasnost’ 64, 78–84 (2019).
M. V. Zheltonozhskaya, E. N. Lykova, A. P. Chernyaev, and V. N. Yatsenko, “Investigation of the flow of secondary particles of a medical electron accelerator,” Izv. Ross. Akad. Nauk. Ser. Fiz. 83, 1003–1008 (2019).
R. M. Howell, S. B. Scarboro, S. F. Kry, and D. Z. Yaldo, “Accuracy of out-of-field dose calculations by a commercial treatment planning system,” Phys. Med. Biol. 55, 6999–7008 (2010).
J. Y. Huang, D. S. Followill, X. A. Wang, and S. F. Kry, “Accuracy and sources of error of out-of-field dose calculations by a commercial treatment planning system for intensity-modulated radiation therapy treatments,” J. Appl. Clin. Med. Phys. 14, 186—197 (2013).
E. N. Lykova, “Investigation of flows of secondary particles during the operation of a medical accelerator with an energy of 18–20 MeV,” Thesis (Mosk. Gos. Univ., Moscow, 2019).
E. N. Lykova, E. P. Morozova, A. F. Petrova, et al., “Measuring doses of radiation leaked from a multileaf collimator on a Varian Halcyon accelerator,” Bull. Russ. Acad. Sci. 86, 460—464 (2022).
A. A. Loginova, D. A. Tovmasian, A. O. Lisovskaya, et al., “Optimized conformal total body irradiation methods with helical tomotherapy and elekta vmat. implementation, imaging, planning and dose delivery for pediatric patients,” Front. Oncol. 12, 785917 (2022).
A. A. Loginova, D. A. Kobyzeva, A. A. Nechesnyuk, et al., “Comparison of treatment plans for total body irradiation (TBI) using volume-modulated rotational radiation therapy and helical tomotherapy,” Issled. Praktika Med. 5, 86 (2018).
A. W. Hoeben Bianca, M. Pazos, E. Seravalli et al., “ESTRO ACROP and SIOPE recommendations for myeloablative total body irradiation in children,” Radiother. Oncol. 173, 119–133 (2022).
D. A. Tovmasyan, A. A. Loginova, A. P. Chernyaev, and A. V. Nechesnyuk, “Non-standard use of tomotherapy exit imaging detectors for quality assurance procedures,” Moscow Univ. Phys. Bull. 76, 470–476 (2021).
S-I. Su Jung An, Cheol-Ha Beak, Kisung Lee, and Yong Hyun Chung, “A simulation study of a C-shaped in-beam PET system for dose verification in carbon ion therapy,” Nucl. Instr. Meth. Phys. Res., Sect. A 698, 37—43 (2013).
F. Ponisch, K. Parodi, B. G. Hasch, and W. Enghardt, “The modelling of positron emitter production and pet imaging during carbon ion therapy,” Phys. Med. Biol. 49, 5217–5232 (2004).
A. G. Sinel’nikov, A. P. Chernyaev, A. A. Shcherbakov, et al., Bull. Russ. Acad. Sci.: Phys. 86, 927–930 (2022).
M. A. Zubkov, A. E. Andreichenko, and E. I. Kretov, “Ultrahigh field magnetic resonance imaging: new frontiers and possibilities in human imaging,” Phys. Usp. 62, 1214–1232 (2019).
E. P. Pappas, Mukhtar Alshanqity, and A. Moutsatsos, “MRI-related geometric distortions in stereotactic radiotherapy treatment planning: evaluation and dosimetric impact,” Technol. Cancer Res. Treat. 16, 1120—1129 (2017).
X. Liu, Z. Li, Y. Rong, M. Cao, and H. Li, “A comparison of the distortion in the same field MRI and MR-linac system with a 3D printed phantom,” Front. Oncol. 11, 579451 (2021).
I. V. Myaekivi, Evaluation of the influence of distortion in the image of magnetic resonance imaging on the planning of radiotherapy,” MS Thesis (Moscow, 2022).
K. A. Urazova, G. E. Gorlachev, A. P. Chernyaev, and A. V. Golanov, “Diffusion magnetic resonance imaging data: development of methods and tools for diagnosis and treatment of brain diseases,” Bull. Siberian Med. 20, 191–201 (2021).
N. A. Antipina, K. A. Urazova, A. S. Kuznetsova, and A. V. Golanov, “Evaluation and comparison of dosimetric parameters for cyberknife and novalis stereotactic radiotherapy of brain tumours,” J. Radiosurgery SBRT 5, P015 (2017).
K. M. Hasan, I. S. Walimuni, H. Abid, and K. R. Hahn, “A review of diffusion tensor magnetic resonance imaging computational methods and software tools,” Comp. Biol. Med. No. 41 (12), 1062–1072 (2011). https://doi.org/10.1016/j.compbiomed.2010.10.008
K. M. Hasan, I. S. Walimuni, H. Abid, and K. R. Hahn, “A review of diffusion tensor magnetic resonance imaging computational methods and software tools,” Comp. Biol. Med. No. 41 (12), 1062–1072 (2011). https://doi.org/10.1016/j.compbiomed.2010.10.008
R. O. Duda and P. E. Hart, Pattern Classification and Scene Analysis (Wiley, 1973).
K. A. Urazova, G. E. Gorlachev, and A. P. Chernyaev, “Brain tractography based on diffusion data of magnetic resonance imaging,” Med. Fiz. No. 3, 114—129 (2019).
J. Bertholet et al., “Real-time intrafraction motion monitoring in external beam radiotherapy,” Phys. Med. Biol. 64, 15TR01 (2019). https://doi.org/10.1088/1361-6560/ab2ba8
T. Kubiak, “Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation, Braz. J. Radiol. 89, 20150275 (2016). https://doi.org/10.1259/bjr.20150275
V. Balakin, A. Bazhan, V. Alexandrov, A. Pryanichnikov, A. Shemyakov, and A. Shestopalov, “Status of Protom synchrotrons for proton therapy, Int. J. Part. Ther. 7, 198—199 (2021).
Wang et al., “Evaluation and comparison of New 4DCT based strategies for proton treatment planning for lung tumors,” Rad. Oncol. 8, 73 (2013).
M. S. Belikhin, I. N. Grigoryeva, A. A. Zavestovskaya, A. P. Pryanichnikov, A. E. Chernyaev, and A. E. Shemyakov, “Experimental study of the target motion effect on the dose distribution in scanning proton beam therapy,” Bull. Lebedev Phys. Inst. 49, 132—136 (2022).
M. Belikhin, A. Pryanichnikov, A. Shemyakov, and A. Chernyaev, “Experimental dosimetric estimation of volume rescanning for spot scanning proton therapy,” Phys. Med. 94, 86—87 (2022).
M. A. Belikhin, A. P. Chernyaev, A.A. Pryanichnikov, and A.E. Shemyakov, “Experimental simulation of volume repainting technique at proton synchrotron in context of spot scanning proton therapy,” in Proceedings of Russian Particle Accelerator Conference RuPAC’21, 2021, pp. 192–195.
A. Pryanichnikov, P. Zhogolev, A. Shemyakov, M. Belikhin, and A. Chernyaev, “Development of the low intensity beam extraction mode for proton imaging at Protom synchrotron, Phys. Med. 94, 113 (2022).
A. A. Pryanichnikov, P. B. Zhogolev, A. E. Shemyakov, M. A. Belikhin, A. P. Chernyaev, and V. Rykalin, “Low intensity beam extraction mode on the Protom synchrotron for proton radiography implementation,” J. Phys.: Conf. Ser. 2058, 012041 (2021).
A. Pryanichnikov, P. Zhogolev, A. Shemyakov, M. Belikhin, and V. Rykalin, “New beam extraction mode on Protom synchrotrons for proton tomography,” Int. J. Part. Therapy 7, 158 (2021).
A. Roberts et al., “Measured bremsstrahlung photonuclear production of 99Mo (99mTc) with 34 MeV to 1.7 GeV electrons,” Appl. Rad. Isotopes 96, 122—128 (2015).
C. Loveless et al., “Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc,” EJNMMI Res. 9, 42 (2019).
R. Aliev et al., “Photonuclear production of medically relevant radionuclide 47Sc,” J. Radioanal. Nucl. Chem. 326, 1099–1106 (2020).
G. Hovhannisyan, T. Bakhshiyan, and R. Dallakyan, “Photonuclear production of the medical isotope 67Cu,” Nucl. Instrum. Methods Phys. Res., Sect. B 498, 48–51 (2021).
M. V. Zheltonozhskaya, V. A. Zheltonozhsky, E. N. Lykova, et al., “Production of zirconium-89 by photonuclear reactions,” Nucl. Instrum. Methods Phys. Res., Sect. B 470, 38–41 (2020). https://doi.org/10.1016/j.nimb.2020.03.002
A. Zheltonozhskiy, M. V. Zheltonozhskaya, P. D. Remizov, et al., “Study of reactions with the emission of protons on 179, 180Hf,” Bull. Russ. Acad. Sci.: Phys. 86, 1309–1314 (2022). https://doi.org/10.3103/S1062873822090349
V. A. Zheltonozhsky, A. M. Savrasov, M. V. Zheltonozhskaya, and A. P. Chernyaev, “Excitation of Lu-177,178 in reactions with bremsstrahlung with esca** of charged particles,” Nucl. Instrum. Methods Phys. Res., Sect. B 476, 68–72 (2020). https://doi.org/10.1016/j.nimb.2020.04.012
V. A. Zheltonozhsky, M. V. Zheltonozhskaya, A. V. Savrasov, et al., “Studying the excitation of k-isomers of 180, 182Hf and 177Lu in (γ, α) reactions,” Phys. Part. Nucl. Lett. 18, 319–322 (2021). https://doi.org/10.1134/S1547477121030134
V. A. Zheltonozhsky, A. M. Savrasov, M. V. Zheltonozhskaya, and A. P. Chernyaev, “Excitation of 180Hfm with (gamma, p)-reaction,” Eur. Phys. J. A 57, 121(2021). https://doi.org/10.1140/epja/s10050-021-00432-9
S. Reddy and M. Robinson, “Immuno-positron emission tomography in cancer models,” Seminars Nucl. Med. 40, 182—189 (2010).
A. Dabkowski et al., “Optimization of cyclotron production for radiometal of zirconium 89,” Acta Phys. Polon. A 127, 1479–1482 (2015).
N. Sairanbayev, S. Koltochnik, A. Shaimerdenov, Y. Chakrova, A. Gurin, and Yu. Kenzhin, “Analysis of lutetium-177 production at the WWR-K research reactor,” Appl. Radiat. Isot. 169, 109561 (2021). https://doi.org/10.1016/j.apradiso.2020.109561
V. V. Rozanov and I. V. Matveichuk, “Current State and promising innovative directions for the development of bioimplant sterilization methods,” Al’manakh Klinich. Med. 47, 634—646 (2019).
Trends in Radiation Sterilization of Health Care Products (IAEA, Vienna, 2008).
H. Nguyen, A. I. Cassady, M. B. Bennett, et al., “Reducing the radiation sterilization dose improves mechanical and biological quality while retaining sterility assurance levels of bone allografts,” Bone 57, 194–200 (2013).
I. V. Matveichuk, V. V. Rozanov, I. K. Gordonova, Z. K. Nikitina, N. I. Sidel’nikov, Yu. Yu. Litvinov, A. A. Nikolaeva, A. P. Chernyaev, and I. V. Panteleev, RF Patent No. 2630464 (2017).
V. V. Rozanov, I. V. Matveichuk, A. P. Chernyaev, N. A. Nikolaeva, and L. N. Savvinova, “Study of the structural and functional characteristics of the surface of bone implants during combined sterilization,” Izv. Ross. Akad. Nauk. Ser. Fiz. 84, 1587—1592 (2020).
F. R. Studenikin, U. A. Bliznyuk, A. P. Chernyaev, et al., “Impact of aluminum plates on uniformity of depth dose distribution in object during electron processing,” Moscow Univ. Phys. Bull. 76, S1–S7 (2021).
U. A. Bliznyuk, P. Yu. Borshchegovskaya, V. S. Ipatova, et al., “Determining the beam spectrum of industrial electron accelerator using depth dose distribution,” Bull. Russ. Acad. Sci.: Phys. 86, 500–507 (2022).
U. Bliznyuk, P. Borshchegovskaya, T. Bolotnik, et al., “Research into gas chromatography–mass spectrometry (gc-ms) for ensuring the effect of 1 MeV-accelerated electrons on volatile organic compounds in turkey meat,” Separations 9, no. 8 (2022).
U. Bliznyuk, V. Avdyukhina, P. Borshchegovskaya, et al., “Effect of electron and x-ray irradiation on microbiological and chemical parameters of chilled turkey,” Sci. Rep. 12, 750 (2022).
A. P. Chernyaev, V. V. Rozanov, M. K. Beklemishev, et al., “Using low-energy electrons for the antimicrobial processing of poultry meat,” Bull. Russ. Acad. Sci.: Phys. 84, 1380–1384 (2020).
N. S. Chulikova, A. A. Malyuga, U. A. Bliznyuk, et al., “Impact of 1-MeV election beam irradiation on the phenology and microflora of potatoes,” Bull. Russ. Acad. Sci.: Phys. 86, 1549–1556 (2022).
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Chernyaev, A.P., Lykova, E.N. State-of-the-Art Nuclear Physics Research in Medicine. Phys. Part. Nuclei Lett. 20, 729–744 (2023). https://doi.org/10.1134/S1547477123040209
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DOI: https://doi.org/10.1134/S1547477123040209