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Synthesis of Ethyl 4-Aryl-2-imino-1-(2-methoxyphenyl)-5-[(2-methoxyphenyl)carbamoyl]-6-oxopiperidine-3-carboxylates

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Abstract

The reaction of ethyl 3-aryl-2-cyanoprop-2-enoates with N1,N3-bis(2-methoxyphenyl)propanedi­amide afforded previously unknown products of intramolecular heterocyclization of the primary Michael adducts, ethyl 4-aryl-2-imino-1-(2-methoxyphenyl)-5-[(2-methoxyphenyl)carbamoyl]-6-oxopiperidine-3-car­box­ylates, in 73–90% yields. The product structure was determined by IR and NMR (1H, 13C) spectroscopy.

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This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia

    A. Kh. Khachatryan, K. A. Avagyan, A. A. Sargsyan & A. E. Badasyan

  2. Crisis Management State Academy, Ministry of Internal Affairs of the Republic of Armenia, 0040, Yerevan, Armenia

    A. Kh. Khachatryan

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  1. A. Kh. Khachatryan
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  2. K. A. Avagyan
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  3. A. A. Sargsyan
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  4. A. E. Badasyan
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Correspondence to A. Kh. Khachatryan.

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Khachatryan, A.K., Avagyan, K.A., Sargsyan, A.A. et al. Synthesis of Ethyl 4-Aryl-2-imino-1-(2-methoxyphenyl)-5-[(2-methoxyphenyl)carbamoyl]-6-oxopiperidine-3-carboxylates. Russ J Org Chem 60, 743–746 (2024). https://doi.org/10.1134/S1070428024040250

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