Abstract
A one-pot efficient, green, and environmentally friendly multicomponent synthesis of novel 2H-pyrano[2,3-d][1,3]thiazole-6-carbonitriles has been performed in a green, low cost, mild, efficient, and commercially available 2,2,2-trifluoroethanol as solvent in the presence of a Lewis acid catalyst under ultrasonic irradiation at room temperature. The reaction was conducted with 2-chloroacetic acid, ammonium thiocyanate, aryl aldehydes, and malononitrile. This method has the advantages of high yield, clean reaction, short reaction time, simple operation, and no use of hazardous organic solvents. The synthesized compounds were characterized by 1H and 13C NMR, IR, and mass spectra and elemental analyses and were screened for antimicrobial activities. Some of the compounds exhibited promising antibacterial and antifungal activities.
REFERENCES
Kamlet, M.J., Abboud, J.L.M., Abraham, M.H., and Taft, R.W., J. Org. Chem., 1983, vol. 48, p. 2877. https://doi.org/10.1021/jo00165a018
Middleton, W.J. and Lindsey, R.V., Jr., J. Am. Chem. Soc., 1964, vol. 86, p. 4948. https://doi.org/10.1021/ja01076a041
Leonard, N.J. and Neelima, Tetrahedron Lett., 1995, vol. 36, p. 7833. https://doi.org/10.1016/0040-4039(95)01673-6
Schadt, F.L., Bentley, T.W., and Schleyer, P.V.R., J. Am. Chem. Soc., 1976, vol. 98, p. 7667. https://doi.org/10.1021/ja00440a037
Allard, B., Casadevall, A., Casadevall, E., and Largeau. C., Inorg. Chim. Acta, 1980, vol. 40, p. X159. https://doi.org/10.1016/S0020-1693(00)92275-8
Reichardt, C., Chem. Rev., 1994, vol. 94, p. 2319. https://doi.org/10.1021/cr00032a005
Eberson, L., Hartshorn, M.P., and Persson, O., J. Chem. Soc., Perkin Trans. 2, 1995, p. 1735. https://doi.org/10.1039/P29950001735
Khurana, J.M. and Kumar, S., Tetrahedron Lett., 2009, vol. 50, p. 4125. https://doi.org/10.1016/j.tetlet.2009.04.125
**, T.-S., Wang, A.-Q., Shi, F., Han, L.-S., Liu, L.-B., and Li, T.-S., Arkivoc, 2006, vol. 2006, part (xiv), p. 78. https://doi.org/10.3998/ark.5550190.0007.e11
Smith, P.W., Sollis, S.L., Howes, P.D., Cherry, P.C., Starkey, I.D., Cobley, K.N., Weston, H., Scicinski, J., Merritt, A., Whittington, A., Wyatt, P., Taylor, N., Green, D., Bethell, R., Madar, S., Fenton, E.J., Morley, P.J., Pateman, T., and Beresford, A., J. Med. Chem., 1998, vol. 41, p. 787. https://doi.org/10.1021/jm970374b
Fang, D., Zhang, H.-B., and Liu, Z.-L., J. Heterocycl. Chem., 2009, vol. 47, p. 63. https://doi.org/10.1002/jhet.254
Chen, L., Li, Y.-Q., Huang, X.-J., and Zheng, W.-J., Heteroat. Chem., 2009, vol. 20, p. 91. https://doi.org/10.1002/hc.20516
Shaabani, A., Samadi, S., Badri, Z., and Rahmati, A., Catal. Lett., 2005, vol. 104, p. 39. https://doi.org/10.1007/s10562-005-7433-2
Wang, L.M., Shao, J.-H., Tian, H., Wang, Y.-H., and Liu, B., J. Fluorine Chem., 2006, vol. 127, p. 97. https://doi.org/10.1016/j.jfluchem.2005.10.004
Hekmatshoar, R., Majedi, S., and Bakhtiari, K., Catal. Commun., 2008, vol. 9, p. 307. https://doi.org/10.1016/j.catcom.2007.06.016
Seifi, M. and Sheibani, H., Catal. Lett., 2008, vol. 126, p. 275. https://doi.org/10.1007/s10562-008-9603-5
Kumar, D., Reddy, V.B., Mishra, B.G., Rana, R.L., Nadagouda, M.N., and Varma, R.S., Tetrahedron, 2007, vol. 63, p. 3093. https://doi.org/10.1016/j.tet.2007.02.019
Heravi, M.M., Jani, B.A. Derikvand, F., Bamoharram, F.F., and Oskooie, H.A., Catal. Commun., 2008, vol. 10, p. 272. https://doi.org/10.1016/j.catcom.2008.08.023
Mohammadi Ziarani, G., Badiei, A.R., Azizi, M., and Zarabadi, P., Iran. J. Chem. Chem. Eng., 2011, vol. 30, p. 59. http://magiran.com/p900724
Balalaie, S., Bararjanian, M., Sheikh-Ahmadi, M., Hekmat, S., and Salehi, P., Synth. Commun., 2007, vol. 37, p. 1097. https://doi.org/10.1080/00397910701196579
Abdolmohammadi, S. and Balalaie, S., Tetrahedron Lett., 2007, vol. 48, p. 3299. https://doi.org/10.1016/j.tetlet.2007.02.135
Hasaninejad, A., Shekouhy, M., Golzar, N., Abdolkarim Zare, M., and Doroodmand, M.M., Appl. Catal., A, 2011, vol. 402, p. 11. https://doi.org/10.1016/j.apcata.2011.04.012
Khurana, J.M., Nand, B., and Saluja, P., Tetrahedron, 2010, vol. 66, p. 5637. https://doi.org/10.1016/j.tet.2010.05.082
Khalil, A., Elsayed, G.A., Mohamed, H.A., and Raafat, A., J. Iran. Chem. Soc., 2018, vol. 15, p. 191. https://doi.org/10.1007/s13738-017-1223-9
Das, P., Dutta, A., Bhaumik, A., and Mukhopadhyay, C., Green Chem., 2014, vol. 16, p. 1426. https://doi.org/10.1039/C3GC42095G
Poor Heravi, M.R., Hemmati, S., Nami, N., and Khalilzadeh, M.A., Polycyclic Aromat. Compd., 2021, vol. 41, p. 2263. https://doi.org/10.1080/10406638.2019.1711432
Lesyk, R.B. and Zimenkovsky, B.S., Curr. Org. Chem., 2004, vol. 8, p. 1547. https://doi.org/10.2174/1385272043369773
Verma, A. and Saraf, S.K., Eur. J. Med. Chem., 2008, vol. 43, p. 897. https://doi.org/10.1016/j.ejmech.2007.07.017
Lesyk, R.B., Zimenkovsky, B.S., Kaminsky, D.V., Kryshchyshyn, A.P., Havrylyuk, D.Y., Atamanyuk, D.V., Subtel’na, I.Y., and Khylyuk, D.V., Biopolym. Cell, 2011, vol. 27, p. 107. https://doi.org/10.7124/bc.000089
Tripathi, A.C., Gupta, S.J., Fatima, G.N., Sonar, P.K., Verma, A., and Saraf, S.K., Eur. J. Med. Chem., 2014, vol. 72, p. 52. https://doi.org/10.1016/j.ejmech.2013.11.017
Schaal, H., Häber, T., and Suhm, M.A., J. Phys. Chem. A, 2000, vol. 104, p. 265. https://doi.org/10.1021/jp9928558
Bégué, J.P., Bonnet-Delpon, D., and Crousse, B., Synlett, 2004, vol. 2004, no. 1, p. 18. https://doi.org/10.1055/s-2003-44973
Poor Heravi, M.R., Danafar, M., and Poor Heravi, N., Lett. Org. Chem., 2019, vol. 16, p. 922. https://doi.org/10.2174/1570178616666190315155330
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Shabani, N., Heravi, M.R.P., Babazadeh, M. et al. Green Synthesis of 2H-Pyrano[2,3-d][1,3]thiazole-6-carbonitriles in Trifluoroethanol as an Efficient Acidic Solvent and Their Biological Activity. Russ J Org Chem 60, 115–124 (2024). https://doi.org/10.1134/S1070428024010159
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DOI: https://doi.org/10.1134/S1070428024010159