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Deep Eutectic Solvent-Assisted Synthesis of Thiopyrans from β-Oxodithioesters (β-ODE) and Their Antibacterial Properties

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Abstract

The use of biodegradable and recyclable deep eutectic solvent (DES) based on choline chloride and urea for the synthesis of 4H-thiopyrans has been reported. The reaction proceeds efficiently under mild conditions without the use of an additional catalyst with better yields. The ease of recovery and reusability of solvent with consistent activity makes this method efficient and environmentally benign. This method is also energy efficient and easy to handle. The synthesized compounds were evaluated for antibacterial activities. The highest antibacterial activity against the tested bacteria Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Salmonella typhi was observed for 2-amino-5-(4-chlorobenzoyl)-4-(4-chlorophenyl)-6-(methylsul­fanyl)-4H-thiopyran-3-carbonitrile.

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Authors and Affiliations

  1. Chemistry Department, Manipur University, 795003, Canchipur, India

    L. M. Devi, T. L. Devi, T. P. Singh & O. M. Singh

  2. Botany Department, Manipur University, 795003, Canchipur, India

    N. K. Singh

Authors
  1. L. M. Devi
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  2. T. L. Devi
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  4. T. P. Singh
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L. M. Devi and T. L. Devi made equal contributions to this study.

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Correspondence to O. M. Singh.

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Devi, L.M., Devi, T.L., Singh, N.K. et al. Deep Eutectic Solvent-Assisted Synthesis of Thiopyrans from β-Oxodithioesters (β-ODE) and Their Antibacterial Properties. Russ J Org Chem 59, 679–688 (2023). https://doi.org/10.1134/S1070428023040176

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