Abstract
A biocompatible supramolecular system based on sodium alginate and viologen calix[4]resorcinol for encapsulation of doxorubicin hydrochloride (DOX) has been obtained. Using a set of physicochemical methods, the polymer–macrocycle ratio, at which stable nanoparticles are formed, has been found and their morphological characteristics have been determined. It has been shown that the increase in the concentration of calix[4]resorcinol leads to the increase in the size of nanoparticles, their zeta potential being changed from negative to positive values. It has been established that the optimal supramolecular system for DOX binding is a composition with a macrocycle–polymer ratio of 1 : 50, and a change in the components ratio can induce the drug release. The effect of encapsulated DOX on the physicochemical and biological properties of the supramolecular system has been shown.
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This study was financially supported by Russian Science Foundation (project no. 22-73-10050).
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L.Ya. Zakharova is a member of Editorial Board of Russian Journal of General Chemistry. Other authors declare that they have no conflicts of interest.
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Kashapov, R.R., Razuvayeva, Y.S., Ziganshina, A.Y. et al. Development of Doxorubicin Complex with Nanoparticles Based on Sodium Alginate and Viologen Calix[4]resorcinol to Enhance Selectivity of the Cytotoxic Action. Russ J Gen Chem 93, 1409–1419 (2023). https://doi.org/10.1134/S1070363223060129
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DOI: https://doi.org/10.1134/S1070363223060129