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Supramolecular Systems Based on Sodium Alginate and Viologen Calix[4]resorcinol Capable of Encapsulating Hydrophobic Compounds

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Abstract

The supramolecular system based on viologen calix[4]resorcinol and sodium alginate in an aqueous medium was studied by a set of physicochemical methods. It was found that sodium alginate and viologen calix[4]resorcinol in the range of macrocycle : polymer concentration ratios from 1 : 2 to 1 : 10 form stable nanoparticles capable of encapsulating biologically active hydrophobic substances. In the presence of encapsulated substrates, the selectivity of the action of quercetin and oleic acid against M-HeLa tumor cells increases by 2.47 and 1.14 times, respectively.

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Funding

This work was supported by the Russian Science Foundation (grant no. 22-73-10050).

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Authors and Affiliations

  1. A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, 420088, Kazan, Russia

    R. R. Kashapov, Yu. S. Razuvayeva, A. Yu. Ziganshina, A. S. Sapunova, A. D. Voloshina & L. Ya. Zakharova

  2. Kazan Institute of Biochemistry and Biophysics, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, 420111, Kazan, Russia

    V. V. Salnikov

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  1. R. R. Kashapov
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  2. Yu. S. Razuvayeva
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  3. A. Yu. Ziganshina
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Correspondence to R. R. Kashapov.

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L.Ya. Zakharova is a member of the editorial board of the Journal of General Chemistry. Other authors declare no conflicts of interest.

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Kashapov, R.R., Razuvayeva, Y.S., Ziganshina, A.Y. et al. Supramolecular Systems Based on Sodium Alginate and Viologen Calix[4]resorcinol Capable of Encapsulating Hydrophobic Compounds. Russ J Gen Chem 93, 1144–1154 (2023). https://doi.org/10.1134/S1070363223050158

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