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Synthesis and Cytotoxic Activity of Novel Chalcone Analogues with Pyridine-2,4(1Н,3Н)-dione Fragment

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Abstract

New heterocyclic chalcone analogues with pyridine-2,4(1Н,3Н)-dione fragment were synthesized by the condensation reaction of 3-acetylpyridine-2,4(1H,3H)-diones with different aromatic aldehydes in pyridine in the presence of a catalytic amount of piperidine and acetic acid. Structures of the synthesized compounds were confirmed by of IR, 1H, 13C NMR spectroscopy methods and two-dimensional NMR spectroscopy methods and elemental analysis data. Cytotoxic activity of the series of obtained compounds was investigated in vitro against human cell lines of breast cancer (MCF-7) and liver cancer (Hep G2).

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 220084, Minsk, Belarus

    T. S. Khlebniсova, D. B. Rubinov, A. V. Baranovsky, F. S. Pashkovsky, T. V. Chukarina & S. E. Ogurtsova

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  1. T. S. Khlebniсova
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  2. D. B. Rubinov
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  3. A. V. Baranovsky
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  4. F. A. Lakhvich
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  5. F. S. Pashkovsky
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  6. T. V. Chukarina
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  7. S. E. Ogurtsova
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Correspondence to T. S. Khlebniсova.

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Khlebniсova, T.S., Rubinov, D.B., Baranovsky, A.V. et al. Synthesis and Cytotoxic Activity of Novel Chalcone Analogues with Pyridine-2,4(1Н,3Н)-dione Fragment. Russ J Gen Chem 93, 476–484 (2023). https://doi.org/10.1134/S1070363223030039

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