Abstract
For the first time, the synthesis of water-soluble copper-containing microcrystalline cellulose sulfates (Сu-MCS) has been performed by the ion exchange method. The composition of the products has been studied by chemical methods and X-ray spectral microanalysis. The copper content in the Сu-MCS samples was 12.6–14.1%. The absence of sodium in the resulting polymer indicates the complete substitution of the sodium cations by the copper cations in the sodium salt of MCC sulfate. The structure of the copper-containing sulfates of microcrystalline cellulose has been confirmed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and electron paramagnetic resonance (EPR). According to the XRD method, Сu-MCS and Na-MCS have an amorphous structure in contrast to the original MCC samples, which have a high degree of crystallinity. The EPR data have demonstrated the formation of a pseudocrystalline structure of the copper-containing salt system in the Сu-MCS samples. As shown by atomic-force microscopy, the surface of the Сu-MCS films consists of homogeneous crystallites, which have a spherical or slightly extended form with the size of about 70 nm. The film surface is quite homogeneous in its phase composition and contains no impurities.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Reis, R.L., Neves, N.M., Mano, J.F., Gomes, M.E., Marques, A.P., and Azevedo, H.S., Natural-Based Polymers for Biomedical Applications, Cambridge: Woodhead Publishing Limited, 2008.
Varshosaz, J., Dextran conjugates in drug delivery, Expert Opin. Drug Deliv., 2012, vol. 9, no. 5, pp. 509–523.
Santander-Ortega, M.J., Stauner, T., Loretz, B., Ortega-Vinuesa, J.L., Bastos-González, D., Wenz, G., Schaefer, U.F., and Lehr, C.M., Nanoparticles made from novel starch derivatives for transdermal drug delivery, J. Control. Release, 2010, vol. 141, no. 1, pp. 85–92.
Edgar, K.J., Cellulose esters in drug delivery, Cellulose, 2007, vol. 14, no. 1, pp. 49–64.
Sibikina, O.V., Iozep, A.A., and Moskvin, A.V., Polysaccharide complexes with metal cations: application and structure (review), Khim.-Farm. Zh., 2009, vol. 43, no. 6, pp. 35–39.
Avtsyn, A.P., Zhavoronkov, A.A., Rish, M.A., and Strochkova, L.S., Mikroelementy cheloveka (etiologiya, klassifikatsiya, organopatologiya) (Micronutrients of Humans (Etiology, Classification, and Organopathology)), Moscow, 1991.
Son, W., Youk, J.H., and Park, W.H., Antimicrobial cellulose acetate nanofibers containing silver nanoparticles, Carbohydr. Res., 2006, vol. 65, no. 4, pp. 430–434.
Nadagouda, M.N. and Varma, R.S., Synthesis of thermally stable carboxymethyl cellulose/metal biodegradable nanocomposites for potential biological applications, Biomacromolecules, 2007, vol. 8, no. 9, pp. 2762–2767.
Danilov, V.G., Yatsenkova, O.V., Kuznetsova, S.A., and Kuznetsov, B.N. A method for obtaining microcrystalline cellulose, RF Patent no. 2203995, 2003.
Obolenskaya, A.V., El’nitskaya, Z.P., and Leonovich, A.A., Laboratornye raboty po khimii drevesiny i tsellyulozy: uchebnoe posobie dlya vuzov (Laboratory Works on the Chemistry of Wood and Cellulose: A Textbook for High Schools), Moscow, 1991.
Baiklz, N. and Segal, L., Tsellyuloza i ee proizvodnye (Cellulose and Its Derivatives), Moscow, 1974, vol. 1.
Levdanskii, V.A., Levdanskii, A.V., and Kuznetsov, B.N., Sulfation of microcrystalline cellulose with chlorosulfonic acid in dioxane, Khim. Rastit. Syr’ya, 2012, no. 1, pp. 39–44.
Zagorodni, A.A., Ion Exchange Materials: Properties and Applications, Amsterdam: Elsevier, 2006.
Podchainova, V.N. and Simonova, L.N., Analiticheskaya khimiya elementov. Med’ (Analytical Chemistry of Elements. Copper), Moscow, 1990.
GOST 2789–73 (Rekomendatsiya ISO R 486) Sherokhovatost’ poverkhnosti. Parametry i kharakteristiki (GOST 2789–73 (Recommendation ISO R 486) Surface Roughness: Parameters and Characteristics), Moscow, 2006.
Levdanskii, V.A., Kazachenko, A.S., Levdanskii, A.V., and Kuznetsov, B.N., Study of microcrystalline cellulose sulphates obtained using chlorosulphonic and sulphamic acids, Zh. Sib. Fed. Univ., Ser. Khim., 2016, vol. 9, no. 1, pp. 119–133.
Ardizzone, S., Dioguardi, F.S., Mussini, T., Mussini, P.R., Rondinini, S., Vercelli, B., and Vertova, A., Microcrystalline cellulose powders: structure, surface features and water sorption capability, Cellulose, 1999, vol. 6, no. 1, pp. 57–69.
Al’tshuler, S.A. and Kozyrev, B.M., Elektronnyi paramagnitnyi rezonans soedinenii elementov promezhutochnykh grupp (Electron Paramagnetic Resonance of Compounds Formed by Elements of Intermediate Groups), Moscow, 1972.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A.V. Levdansky, N.Yu. Vasilyeva, N.G. Maximov, A.A. Karacharov, V.A. Levdansky, G.P. Skvortsova, B.N. Kuznetsov, L. Djakovitch, C. Pinel, 2017, published in Khimiya Rastitel’nogo Syr’ya, 2017, No. 3, pp. 55–61.
Rights and permissions
About this article
Cite this article
Levdansky, A.V., Vasilyeva, N.Y., Maximov, N.G. et al. Synthesis and Study of Copper-Containing Polymers of Microcrystalline Cellulose Sulfates from Larch Wood. Russ J Bioorg Chem 44, 834–838 (2018). https://doi.org/10.1134/S1068162018070063
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1068162018070063