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Synthesis of the betulin dipropionate from the upper birch bark

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Abstract

A one-step synthesis of the betulin dipropionate directly from the birch bark without a separate stage of the betulin preparation is described in this paper. Extracts with different content of the betulin dipropionate were shown to form depending on the conditions of acylation of the upper birch bark with propionic acid. The product with the maximum content of the betulin dipropionate was prepared from the starting fraction of 2–5 mm of the upper birch bark and the fraction of 10–20 mm that was preliminarily activated with superheated water vapor. The upper bark extract was analyzed by gas chromatography. The structure of betulin dipropionate was confirmed by element analysis, 1H NMR, 13C NMR, and FTIR spectroscopy.

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Authors and Affiliations

  1. Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences, ul. Karla Marksa 42, Krasnoyarsk, 660049, Russia

    S. A. Kuznetsova, G. P. Skvortsova, Yu. N. Malyar, V. A. Sokolenko & B. N. Kuznetsov

  2. Siberian Federal University, pr. Svobodnyi 79, Krasnoyarsk, 660041, Russia

    S. A. Kuznetsova & B. N. Kuznetsov

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  1. S. A. Kuznetsova
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  2. G. P. Skvortsova
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  3. Yu. N. Malyar
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  4. V. A. Sokolenko
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  5. B. N. Kuznetsov
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Correspondence to S. A. Kuznetsova.

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Original Russian Text © S.A. Kuznetsova, G.P. Skvortsova, Yu.N. Malyar, V.A. Sokolenko, B.N. Kuznetsov, 2011, published in Khimija Rastitel’nogo Syr’ja, 2011, No. 4, pp. 77–82.

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Kuznetsova, S.A., Skvortsova, G.P., Malyar, Y.N. et al. Synthesis of the betulin dipropionate from the upper birch bark. Russ J Bioorg Chem 38, 743–748 (2012). https://doi.org/10.1134/S1068162012070126

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