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The Influence of the Sizes of Nanodiamond Aggregates in Suspensions on the Efficiency of Sorption of 90Y and 177Lu Isotopes for Further Use in Nuclear Medicine

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Radiochemistry Aims and scope

Abstract

Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for the use in nuclear medicine. In this work, we investigated the influence of the properties of NDs suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes 90Y and 177Lu and determination of conditions for fabricating promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the NDs surface, while the forms of cations of the studied nuclides in the solution do not affect the sorption value.

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ACKNOWLEDGMENTS

The authors are grateful to R.Kh. Dzhenloda and A.I. Ivaneev (Institute of Geochemistry and Analytical Chemistry named after V.I. Vernadsky) for performing the DLS analysis.

Funding

The study was supported by a grant from the Russian Science Foundation no. 21-13-00449. https://rscf.ru/project/21-13-00449/.

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Authors and Affiliations

  1. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    A. G. Kazakov, J. S. Babenya, T. Y. Ekatova, S. E. Vinokurov, E. Y. Khvorostinin & B. F. Myasoedov

  2. National Research Tomsk Polytechnic University, 634050, Tomsk, Russia

    I. A. Ushakov, V. V. Zukau, E. S. Stasyuk, E. A. Nesterov, V. L. Sadkin & A. S. Rogov

  3. Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences, 117997, Moscow, Russia

    B. F. Myasoedov

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  1. A. G. Kazakov
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  2. J. S. Babenya
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  3. T. Y. Ekatova
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  4. S. E. Vinokurov
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  5. E. Y. Khvorostinin
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  6. I. A. Ushakov
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  7. V. V. Zukau
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  8. E. S. Stasyuk
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  11. A. S. Rogov
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  12. B. F. Myasoedov
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Correspondence to A. G. Kazakov.

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Kazakov, A.G., Babenya, J.S., Ekatova, T.Y. et al. The Influence of the Sizes of Nanodiamond Aggregates in Suspensions on the Efficiency of Sorption of 90Y and 177Lu Isotopes for Further Use in Nuclear Medicine. Radiochemistry 66, 198–205 (2024). https://doi.org/10.1134/S1066362224020097

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