Abstract
Glycerol derivative triacetin (TA) has diverse applications in the pharmaceutical, fuel, cosmetic, and food industries. Hence, it is vital to quantify triacetin in a given sample before it can be employed for a suitable commercial application. The conventional HPLC based method of TA quantification is time-consuming, leads to generating liquid waste, and requires unique columns, reference materials, and a suitable detector for the identification of molecules under investigation. To simplify TA quantification, herein, we have proposed a quantitative proton nuclear magnetic resonance (qHNMR) based method which does not require any complicated sample preparation method, sample derivatization, long analysis time, or highly pure reference materials. For TA quantification, an equation based on proton NMR analysis of standard mixtures of TA and glycerol of variable compositions is proposed. To validate the developed method, TA was quantified in samples with its variable concentrations by either qHNMR or HPLC, and the results were found to be comparable (R2 = 0.99). Further, to demonstrate the practical application, the technique was employed to quantify TA formed during acetylation of glycerol with acetic acid at various time intervals.
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ACKNOWLEDGMENTS
We are thankful to SAI Lab (Thapar Institute of Engineering and Technology, Patiala, India) for NMR study.
Funding
We acknowledge DST-SERB (Ref no.: EMR/2014/000090) and CSIR (Ref no.: 01(2964)/18/EMR-II) for the financial support; DST-FIST (Ref. no.: SR/FST/CSI-217/2010) for funding instrumentation facility in the School of Chemistry and Biochemistry.
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Abida, K., Ali, A. Quantification of Triacetin in a Mixture of Tri-, Di-, Monoacetin and Glycerol by qHNMR Technique. J Anal Chem 78, 480–487 (2023). https://doi.org/10.1134/S1061934823040032
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DOI: https://doi.org/10.1134/S1061934823040032