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Potentiometric Sensors Sensitive to Some Cephalosporin Antibiotics: Properties and Applications

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Abstract

We developed unmodified and modified solid-contact potentiometric sensors (tubular and screen-printed) for determining some cephalosporin antibiotics in aqueous media, biological fluids, and pharmaceutical preparations. Tetraalkylammonium compounds with silver(I)–β-lac [Ag(β-lac)2] complex compounds were used as active membrane components; carbon nanotubes, polyaniline, and copper oxide and NiZnFeO nanoparticles were used as modifiers. The main electroanalytical and operational characteristics of the studied sensors in aqueous solutions of antibiotics and oral fluid were determined. The sensors ensure the determination of antibiotics in a wide analytical range of 1 × 10–4 (1 × 10–5)–1 × 10–2 (0.1) M; the values of cmin = n × 10–5 (1 × 10–6) M. The modifiers stabilize the electrode potential and act as electron transfer mediators, improving the electroanalytical characteristics of the sensors. Solid-contact sensors can be used to determine the main substances in drugs from various manufacturers and model aqueous solutions and oral fluid with added antibiotics and as consistuents of “electronic tongue” multisensor systems for the separate determination of cephalosporin antibiotics in two-component mixtures.

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Authors and Affiliations

  1. Chernyshevsky Saratov National Research State University, 410012, Saratov, Russia

    E. G. Kulapina & E. N. Cherdakova

  2. Razumovsky State Medical University, 410012, Saratov, Russia

    O. I. Kulapina & V. D. Ankina

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  1. E. G. Kulapina
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  2. O. I. Kulapina
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  3. E. N. Cherdakova
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Correspondence to E. G. Kulapina.

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Translated by O. Zhukova

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Kulapina, E.G., Kulapina, O.I., Cherdakova, E.N. et al. Potentiometric Sensors Sensitive to Some Cephalosporin Antibiotics: Properties and Applications. J Anal Chem 77, 963–973 (2022). https://doi.org/10.1134/S1061934822080056

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