Abstract
A procedure for the determination of a group of perfluororganic compounds, promising for medical use, in whole blood and tissues of laboratory animals by gas-liquid chromatography–mass spectrometry was developed in in vitro experiments. The sample preparation procedure based on the liquid–liquid extraction of the target compounds from the biomaterial with heptane containing perfluorobenzene as an internal standard was optimized. The validation of the procedure and its testing in in vivo experiments was carried out on an example of perfluorodecalin. The time of the presence of the xenobiotic in the bloodstream and in various organs of small laboratory animals during the endotracheal route of administration was estimated.
Similar content being viewed by others
REFERENCES
Kaisers, U., Br. J. Anaesth., 2003, vol. 91, p. 143.
Faithfull, N.S. and Weers, J.G., US Patent 5853003, 1998.
Calderwood, H., Ruiz, B., and Tham, M., J. Appl. Physiol., 1975, vol. 39, p. 603.
Kollpara, S. and Gandhi, R., Acta Pharm. Sin. B, 2014, vol. 4, no. 5, p. 333.
Yamanouchi, K., Murashima, R., and Yokoyama, K., Chem. Pharm. Bull., 1975, vol. 23, no. 6, p. 1363.
Yokoyama, K., Yamanouchi, K., and Murashima, R., Chem. Pharm. Bull., 1975, vol. 23, no. 6, p. 1368.
Okamoto, H., Yamanouchi, K., and Yokoyama, K., Chem. Pharm. Bull., 1975, vol. 23, no. 7, p. 1452.
Yokoyama, K., Yamanouchi, K., Ohyanagi, H., and Mitsuno, T., Chem. Pharm. Bull., 1978, vol. 26, no. 6, p. 956.
Holaday, D., Fiserova-Bergerova, V., and Modell, J., Anesthesiology, 1972, vol. 37, no. 4, p. 387.
Shaffer, T., Wolfson, M., Greenspan, J., Hoffman, R., Davis, S., and Clark, L., Reprod., Fertill. Dev, 1996, no. 8, p. 409.
Clark, L. and Gollan, F., Science, 1966, vol. 152, p. 1755.
Gollan, F. and Clark, L., Physiologist, 1966, vol. 9, p. 191.
Audran M., Krafft M., Ceaurritz J., Maturin J.-C., Sicart M., Marion B., Bougard, G., and Bressolle, F., J. Chromatogr. B: Biomed. Sci. Appl., 2000, vol. 745, p. 333.
Reichardt, Ch., Solvents and Solvent Effects in Organic Chemistry, Weinheim: Verlagsgesellschaft, 1988.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The authors declare that they have no conflicts of interest.
Additional information
Translated by V. Kudrinskaya
Rights and permissions
About this article
Cite this article
Zhurkovich, I.K., Utsal’, V.A., Ostrovidova, E.V. et al. Determination of Perfluororganic Compounds in Whole Blood and Tissues of Laboratory Animals by Gas-Liquid Chromatography–Mass Spectrometry. J Anal Chem 77, 1197–1202 (2022). https://doi.org/10.1134/S1061934822070140
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1061934822070140