Abstract
The glutathione-dependent system of antioxidant defense was studied in the chorionic and placental tissues of women with miscarriage. In the case of spontaneous abortion, the level of glutathione peroxidase reached the maximum even in trimester I and remained more than 1.5-fold higher during the whole gestation period than in the placental tissue of women with physiological pregnancy and delivery. The activity of glutathione reductase in miscarriage was insignificantly different from that in the control group. The activity of glutathione S-transferase in miscarriage was similar to that in the control group during trimester I and remained low during the whole gestation, contributing to a decrease in nonspecific defense in the mother-placenta-fetus system, leading to pathology of the fetus and infant. It is concluded that oxidative stress in the placental tissues is an essential pathogenic factor of miscarriage.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kosheleva, N.G., Arzhanova, O.N., Pluzhnikova, T.A., et al., Nevynashivanie beremennosti: etiopatogenez, klinika i lechenie (Miscarriage: Etiology, Pathogenesis, Clinical Picture, and Treatment), St. Petersburg, 2002.
Prokopenko, V.M., Arutyunyan, A.V., Kuzminykh, T.U., et al., Free Radical Oxidation in the Afterbirth Tissue in Incomplete Pregnancy, Vopr. Med. Khim., 1995, vol. 41, no. 3, p. 53.
Drapier, J.-C. and Hibbs, J. B., Differentiation of Murine Macrophages to Express Nonspecific Cytotoxicity for Tumor Cells Results in L-Arginine-Dependent Inhibition of Mitochondrial Iron-Sulfur Enzymes in the Macrophage Effector Cells, J. Immunol., 1988, vol. 140, p. 2829.
Uyesaka, N., Hasegava, S., Ishioka, N., et al., Effects of Superoxide Anions on Red Cell Deformability and Membrane Proteins, Biorheology, 1992, vol. 29, p. 217.
Hoffman, M.E., Mello-Filho, A.C., and Meneghini, R., Correlation between Cytotoxic Effect of Hydrogen Peroxide and the Yield of DNA Strand Breaks in Cells of Different Species, Biochim. Biophys. Acta, 1984, vol. 781, p. 234.
Prokopenko, V.M., Arutyunyan, A.V., Frolova, E.V., et al., Free Radical Oxidation and Atioxidative Activity in the Placental Tissue in Premature Labor, Byull. Eksp. Biol. Med., 1997, vol. 124, no. 12, p. 632.
Moin, V.M., A Simple and Sensitive Method of Determination of Glutathione Peroxidase in Red Blood Cells, Lab. Delo, 1986, no. 12, p. 724.
Vlasova, S.N., Shabunina, E.I., and Peresigina, I.A., Activities of Glutathione-Dependent Enzymes in Red Blood Cells in Chronic Diseases of Children, Lab. Delo, 1990, no. 8, p. 19.
Arutyunyan, A.V., Dubinina, E.E., and Zybina, N.N., Metody otsenki svobodnoradikal’nogo okisleniya i antioxidantnoi sistemy organizma (Approaches for Assessment of Free Radical Oxidation and Antioxidant System of the Body), V. Kh. Khavinson, Ed., St. Petersburg, 2000, p. 76.
Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J., Protein Measurement with the Folin Phenol Reagent, J. Biol. Chem., 1951, vol. 193, p. 265.
Qanungo, S. and Mukherjea, M., Ontogenic Profile of Some Antioxidants and Lipid Peroxidation in Human Placental and Fetal Tissues, Mol. Cell. Biochem., 2000, vol. 215, p. 11.
Bondar’, T.N., Lankin, V.Z., and Antonovskii, V.L., Reduction of Organic Hydroperoxides with Glutathione Peroxidase and Glutathione S-Transferase: the Effect of the Substrate Structure, Dokl. Akad. Nauk SSSR, 1989, vol. 304, no. 1, p. 217.
Author information
Authors and Affiliations
Additional information
Original Russian Text © V.M. Prokopenko, G.K. Partsalis, S.O. Burmistrov, 2006, published in Fiziologiya Cheloveka, 2006, Vol. 32, No. 2, pp. 84–86.
Rights and permissions
About this article
Cite this article
Prokopenko, V.M., Partsalis, G.K. & Burmistrov, S.O. The glutathione-dependent system of placenta antioxidant defense in miscarriage. Hum Physiol 32, 197–199 (2006). https://doi.org/10.1134/S0362119706020137
Received:
Issue Date:
DOI: https://doi.org/10.1134/S0362119706020137