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Study of the Early Telencephalon Genes of Cyclostomes as a Way to Restoring the Evolutionary History of This Unique Part of the Central Nervous System of Vertebrates

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Abstract

The telencephalon, which provides the highest forms of nervous activity in humans and other animals, is one of the most important innovations of vertebrates. Although this part of the brain has been described in all living vertebrates, its evolutionary origin is still poorly understood. This article discusses one of the possible approaches to studying the expression and functional properties of genes that regulate the early development of the forebrain in cyclostomes (lampreys) as the most archaic representatives of vertebrates. The results of studies of genes such as Anf, FoxG1, and genes of the Noggin family are described.

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Funding

This study was supported by the Russian Foundation for Basic Research (project no. 19-14-50215). Experiments on the study of the FoxG1 and Noggin genes in lampreys were supported by the Russian Foundation for Basic Research (project no. 18-04-00015). Experiments on the analysis of the expression of forehead genes on Xenopus embryos were supported by the Russian Science Foundation (project no. 19-14-00098). Experiments on the functional study of Xenopus forehead genes were supported by the Russian Foundation for Basic Research (project no. 18-29-07014). The study of the Anf gene was supported by the program of the Russian Academy of Sciences “Basic Research for Biomedical Technologies.”

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    G. V. Ermakova, F. M. Eroshkin, N. Yu. Martynova, A. G. Zaraisky & A. V. Bayramov

  2. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, 119071, Moscow, Russia

    A. V. Kucheryavyy

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  1. G. V. Ermakova
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  2. A. V. Kucheryavyy
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  3. F. M. Eroshkin
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  4. N. Yu. Martynova
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  5. A. G. Zaraisky
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  6. A. V. Bayramov
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Correspondence to A. V. Bayramov.

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Ermakova, G.V., Kucheryavyy, A.V., Eroshkin, F.M. et al. Study of the Early Telencephalon Genes of Cyclostomes as a Way to Restoring the Evolutionary History of This Unique Part of the Central Nervous System of Vertebrates. Paleontol. J. 55, 752–765 (2021). https://doi.org/10.1134/S0031030121070030

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