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Structure and urease inhibitory activity of copper(II) complex with (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid

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Abstract

A new caffeic acid derivative ((E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid, HL1)) is synthesized from caffeic acid, followed by the preparation of a Cu(II) complex, [Cu2(L1)4DMSO2]·2DMSO. The structure is determined by single crystal X-ray diffraction, and the urease inhibitory activity of the complex is studied. The results show that IC50 of the complex is 0.56 μmol/L, which is superior to positive control acetohydroxamic acid (AHA, IC50 was 10.95 μmol/l), i.e., the complex has strong inhibitory activity towards urease.

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Authors and Affiliations

  1. School of Life Sciences, Shandong University of Technology, Shandong, P. R. China

    X.-F. Chen, C.-F. Wang, S. Kong, C. Li, X. Zhou, C.-Y. Zhang, G.-H. Sheng & H.-L. Zhu

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  1. X.-F. Chen
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  2. C.-F. Wang
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  3. S. Kong
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  4. C. Li
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  5. X. Zhou
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  6. C.-Y. Zhang
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  7. G.-H. Sheng
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  8. H.-L. Zhu
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Corresponding author

Correspondence to H.-L. Zhu.

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Original Russian Text © 2017 X.-F. Chen, C.-F. Wang, S. Kong, C. Li, X. Zhou, C.-Y. Zhang, G.-H. Sheng, H.-L. Zhu.

The text was submitted by the authors in English.

Zhurnal Strukturnoi Khimii, Vol. 58, No. 4, pp. 827–833, July–August, 2017.

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Chen, XF., Wang, CF., Kong, S. et al. Structure and urease inhibitory activity of copper(II) complex with (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid. J Struct Chem 58, 797–803 (2017). https://doi.org/10.1134/S0022476617040229

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